1yt7: Difference between revisions

@@ Line 1: / Line 1: @@
-[[Image:1yt7.gif|left|200px]]
+{{Seed}}
+[[Image:1yt7.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1yt7|  PDB=1yt7  |  SCENE=  }}
-'''Cathepsin K complexed with a constrained ketoamide inhibitor'''
+===Cathepsin K complexed with a constrained ketoamide inhibitor===
-==Overview==
+<!--
-An orally bioavailable series of ketoamide-based cathepsin K inhibitors with good pharmacokinetic properties has been identified. Starting from a potent inhibitor endowed with poor drug properties, conformational constraint of the P(2)-P(3) linker and modifications to P(1') elements led to an enhancement in potency, solubility, clearance, and bioavailability. These optimized inhibitors attenuated bone resorption in a rat TPTX hypocalcemic bone resorption model.
+The line below this paragraph, {{ABSTRACT_PUBMED_15982880}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15982880 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15982880}}
 ==About this Structure==
@@ Line 44: / Line 48: @@
 [[Category: Cathepsin]]
 [[Category: Cysteine protease]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:45:26 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:30:50 2008''

Navigation menu