2p6u: Difference between revisions

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[[Image:2p6u.jpg|left|200px]]
{{Seed}}
[[Image:2p6u.png|left|200px]]


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{{STRUCTURE_2p6u|  PDB=2p6u  |  SCENE=  }}  
{{STRUCTURE_2p6u|  PDB=2p6u  |  SCENE=  }}  


'''Apo structure of the Hel308 superfamily 2 helicase'''
===Apo structure of the Hel308 superfamily 2 helicase===




==Overview==
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To reveal the mechanism of processive strand separation by superfamily-2 (SF2) 3'--&gt;5' helicases, we determined apo and DNA-bound crystal structures of archaeal Hel308, a helicase that unwinds lagging strands and is related to human DNA polymerase theta. Our structure captures the duplex-unwinding reaction, shows that initial strand separation does not require ATP and identifies a prominent beta-hairpin loop as the unwinding element. Similar loops in hepatitis C virus NS3 helicase and RNA-decay factors support the idea that this duplex-unwinding mechanism is applicable to a broad subset of SF2 helicases. Comparison with ATP-bound SF2 enzymes suggests that ATP promotes processive unwinding of 1 base pair by ratchet-like transport of the 3' product strand. Our results provide a first structural framework for strand separation by processive SF2 3'--&gt;5' helicases and reveal important mechanistic differences from SF1 helicases.
The line below this paragraph, {{ABSTRACT_PUBMED_17558417}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17558417 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17558417}}


==About this Structure==
==About this Structure==
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[[Category: Dna repair]]
[[Category: Dna repair]]
[[Category: Sf2 helicase]]
[[Category: Sf2 helicase]]
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