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| {{STRUCTURE_2rft| PDB=2rft | SCENE= }} | | {{STRUCTURE_2rft| PDB=2rft | SCENE= }} |
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| '''Crystal structure of influenza B virus hemagglutinin in complex with LSTa receptor analog'''
| | ===Crystal structure of influenza B virus hemagglutinin in complex with LSTa receptor analog=== |
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| ==Overview==
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| Receptor-binding specificity of HA, the major surface glycoprotein of influenza virus, primarily determines the host ranges that the virus can infect. Influenza type B virus almost exclusively infects humans and contributes to the annual "flu" sickness. Here we report the structures of influenza B virus HA in complex with human and avian receptor analogs, respectively. These structures provide a structural basis for the different receptor-binding properties of influenza A and B virus HA molecules and for the ability of influenza B virus HA to distinguish human and avian receptors. The structure of influenza B virus HA with avian receptor analog also reveals how mutations in the region of residues 194 to 196, which are frequently observed in egg-adapted and naturally occurring variants, directly affect the receptor binding of the resultant virus strains. Furthermore, these structures of influenza B virus HA are compared with known structures of influenza A virus HAs, which suggests the role of the residue at 222 as a key and likely a universal determinant for the different binding modes of human receptor analogs by different HA molecules.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17942670}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17942670 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17942670}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Viral protein]] | | [[Category: Viral protein]] |
| [[Category: Virion]] | | [[Category: Virion]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 16:50:51 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:11:43 2008'' |
