2uyi: Difference between revisions

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[[Image:2uyi.gif|left|200px]]
{{Seed}}
[[Image:2uyi.png|left|200px]]


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{{STRUCTURE_2uyi|  PDB=2uyi  |  SCENE=  }}  
{{STRUCTURE_2uyi|  PDB=2uyi  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH ADP AND THIOPHENE CONTAINING INHIBITOR 33'''
===CRYSTAL STRUCTURE OF KSP IN COMPLEX WITH ADP AND THIOPHENE CONTAINING INHIBITOR 33===




==Overview==
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We have identified and synthesized a series of thiophene containing inhibitors of kinesin spindle protein. SAR studies led to the synthesis of 33, which was co-crystallized with KSP and determined to bind to an allosteric pocket previously described for other known KSP inhibitors.
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{{ABSTRACT_PUBMED_17498954}}


==About this Structure==
==About this Structure==
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[[Category: Phosphorylation]]
[[Category: Phosphorylation]]
[[Category: Thiophene]]
[[Category: Thiophene]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:48:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:12:38 2008''