1ul1: Difference between revisions

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[[Image:1ul1.gif|left|200px]]
{{Seed}}
[[Image:1ul1.png|left|200px]]


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{{STRUCTURE_1ul1|  PDB=1ul1  |  SCENE=  }}  
{{STRUCTURE_1ul1|  PDB=1ul1  |  SCENE=  }}  


'''Crystal structure of the human FEN1-PCNA complex'''
===Crystal structure of the human FEN1-PCNA complex===




==Overview==
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Flap endonuclease-1 (FEN1) is a key enzyme for maintaining genomic stability and replication. Proliferating cell nuclear antigen (PCNA) binds FEN1 and stimulates its endonuclease activity. The structural basis of the FEN1-PCNA interaction was revealed by the crystal structure of the complex between human FEN1 and PCNA. The main interface involves the C-terminal tail of FEN1, which forms two beta-strands connected by a short helix, the betaA-alphaA-betaB motif, participating in beta-beta and hydrophobic interactions with PCNA. These interactions are similar to those previously observed for the p21CIP1/WAF1 peptide. However, this structure involving the full-length enzyme has revealed additional interfaces that are involved in the core domain. The interactions at the interfaces maintain the enzyme in an inactive 'locked-down' orientation and might be utilized in rapid DNA-tracking by preserving the central hole of PCNA for sliding along the DNA. A hinge region present between the core domain and the C-terminal tail of FEN1 would play a role in switching the FEN1 orientation from an inactive to an active orientation.
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{{ABSTRACT_PUBMED_15616578}}


==About this Structure==
==About this Structure==
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[[Category: Replication]]
[[Category: Replication]]
[[Category: Sliding clamp]]
[[Category: Sliding clamp]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:22:22 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:12:57 2008''

Revision as of 23:13, 28 July 2008

File:1ul1.png

Template:STRUCTURE 1ul1

Crystal structure of the human FEN1-PCNA complex

Template:ABSTRACT PUBMED 15616578

About this Structure

1UL1 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for recruitment of human flap endonuclease 1 to PCNA., Sakurai S, Kitano K, Yamaguchi H, Hamada K, Okada K, Fukuda K, Uchida M, Ohtsuka E, Morioka H, Hakoshima T, EMBO J. 2005 Feb 23;24(4):683-93. Epub 2004 Dec 16. PMID:15616578

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