2v1c: Difference between revisions

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[[Image:2v1c.~~jpg~~|left|200px]]

[[Image:2v1c.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE AND MUTATIONAL STUDY OF RECOR PROVIDE INSIGHT INTO ITS ROLE IN DNA REPAIR~~'''~~

===CRYSTAL STRUCTURE AND MUTATIONAL STUDY OF RECOR PROVIDE INSIGHT INTO ITS ROLE IN DNA REPAIR===

~~==Overview==~~

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The ~~crystal structure of the complex formed between Deinococcus radiodurans RecR and RecO (drRecOR) has been determined. In accordance with previous biochemical characterisation~~, the ~~drRecOR complex displays a RecR:RecO molecular ratio of 2:1. The biologically relevant drRecOR entity consists of a heterohexamer in the form of two drRecO molecules positioned on either side of~~ the ~~tetrameric ring of drRecR, with their OB~~ (~~oligonucleotide~~/~~oligosaccharide-binding) domains pointing towards the interior of the ring~~. ~~Mutagenesis studies validated the protein-protein interactions observed in the crystal structure and allowed mapping of the residues in the drRecOR complex required for DNA binding~~. ~~Furthermore~~, the ~~preferred DNA substrate of drRecOR was identified as being 3'~~-~~overhanging DNA, as encountered at ssDNA~~-~~dsDNA junctions. Together these results suggest a possible mechanism for drRecOR recognition of stalled replication forks.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17581636}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17581636 is the PubMed ID number.

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==About this Structure==

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[[Category: Zinc]]

[[Category: Zinc-finger]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 18~~:01:36 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:16:13 2008''

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-[[Image:2v1c.jpg|left|200px]]
+{{Seed}}
+[[Image:2v1c.png|left|200px]]
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 {{STRUCTURE_2v1c|  PDB=2v1c  |  SCENE=  }}
-'''CRYSTAL STRUCTURE AND MUTATIONAL STUDY OF RECOR PROVIDE INSIGHT INTO ITS ROLE IN DNA REPAIR'''
+===CRYSTAL STRUCTURE AND MUTATIONAL STUDY OF RECOR PROVIDE INSIGHT INTO ITS ROLE IN DNA REPAIR===
-==Overview==
+<!--
-The crystal structure of the complex formed between Deinococcus radiodurans RecR and RecO (drRecOR) has been determined. In accordance with previous biochemical characterisation, the drRecOR complex displays a RecR:RecO molecular ratio of 2:1. The biologically relevant drRecOR entity consists of a heterohexamer in the form of two drRecO molecules positioned on either side of the tetrameric ring of drRecR, with their OB (oligonucleotide/oligosaccharide-binding) domains pointing towards the interior of the ring. Mutagenesis studies validated the protein-protein interactions observed in the crystal structure and allowed mapping of the residues in the drRecOR complex required for DNA binding. Furthermore, the preferred DNA substrate of drRecOR was identified as being 3'-overhanging DNA, as encountered at ssDNA-dsDNA junctions. Together these results suggest a possible mechanism for drRecOR recognition of stalled replication forks.
+The line below this paragraph, {{ABSTRACT_PUBMED_17581636}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17581636 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17581636}}
 ==About this Structure==
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 [[Category: Zinc]]
 [[Category: Zinc-finger]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 18:01:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:16:13 2008''