2p4b: Difference between revisions

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[[Image:2p4b.gif|left|200px]]
{{Seed}}
[[Image:2p4b.png|left|200px]]


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{{STRUCTURE_2p4b|  PDB=2p4b  |  SCENE=  }}  
{{STRUCTURE_2p4b|  PDB=2p4b  |  SCENE=  }}  


'''Crystal structure of E.coli RseB'''
===Crystal structure of E.coli RseB===




==Overview==
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The bacterial envelope stress response senses stress signals in the extracytoplasmic compartment, and activates sigma(E)-dependent transcription by degrading its antisigma factor RseA. RseB, a binding partner of RseA, plays a pivotal role in regulating this response, but its molecular mechanism is not understood. We therefore determined the crystal structure of Escherichia coli RseB at a resolution of 2.4 A. RseB is composed of two domains linked by a flexible linker and forms a loosely packed dimer with two grooves on each side. This structural feature is confirmed by small-angle scattering in solution. Analysis of the binding of various RseA mutants to RseB allowed us to identify the major RseB-binding motif in RseA. These data, coupled with analysis of small-angle scattering of the RseA/RseB complex in solution, leads us to propose that two RseAs bind to the grooves of the dimeric RseB by conserved residues. The implications for modulating proteolytic cleavage of RseA are discussed.
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{{ABSTRACT_PUBMED_17496148}}


==About this Structure==
==About this Structure==
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[[Category: Kim, K K.]]
[[Category: Kim, K K.]]
[[Category: Open and closed form]]
[[Category: Open and closed form]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 12:19:44 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:24:38 2008''

Revision as of 23:24, 28 July 2008

File:2p4b.png

Template:STRUCTURE 2p4b

Crystal structure of E.coli RseB

Template:ABSTRACT PUBMED 17496148

About this Structure

2P4B is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of RseB and a model of its binding mode to RseA., Kim DY, Jin KS, Kwon E, Ree M, Kim KK, Proc Natl Acad Sci U S A. 2007 May 22;104(21):8779-84. Epub 2007 May 11. PMID:17496148

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