2qtw: Difference between revisions

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[[Image:2qtw.~~jpg~~|left|200px]]

[[Image:2qtw.png|left|200px]]

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~~'''~~The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain~~'''~~

===The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain===

~~==Overview==~~

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Mutations in proprotein convertase subtilisin/kexin type 9 (PCSK9) are strongly associated with levels of low-density lipoprotein cholesterol in the blood plasma and, thereby, occurrence or resistance to atherosclerosis and coronary heart disease. Despite this ~~importance~~, ~~relatively little is known about the biology of PCSK9. Here~~, the ~~crystal structure of a full-length construct of PCSK9 solved~~ to 1.~~9-A resolution is presented~~. ~~The structure contains a fully folded C-terminal cysteine-rich domain (CRD~~), showing a distinct structural similarity to the resistin homotrimer, a small cytokine associated with obesity and diabetes. This structural relationship between the CRD of PCSK9 and the resistin family is ~~not observed in primary sequence comparisons and strongly suggests a distant evolutionary link between~~ the ~~two molecules~~. ~~This three~~-~~dimensional homology provides insight into the function of PCSK9 at the molecular level and will help to dissect the link between PCSK9 and CHD.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17804797}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17804797 is the PubMed ID number.

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==About this Structure==

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[[Category: Steroid metabolism]]

[[Category: Zymogen]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 15~~:40:28 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:26:58 2008''

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-[[Image:2qtw.jpg|left|200px]]
+{{Seed}}
+[[Image:2qtw.png|left|200px]]
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 {{STRUCTURE_2qtw|  PDB=2qtw  |  SCENE=  }}
-'''The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain'''
+===The Crystal Structure of PCSK9 at 1.9 Angstroms Resolution Reveals structural homology to Resistin within the C-terminal domain===
-==Overview==
+<!--
-Mutations in proprotein convertase subtilisin/kexin type 9 (PCSK9) are strongly associated with levels of low-density lipoprotein cholesterol in the blood plasma and, thereby, occurrence or resistance to atherosclerosis and coronary heart disease. Despite this importance, relatively little is known about the biology of PCSK9. Here, the crystal structure of a full-length construct of PCSK9 solved to 1.9-A resolution is presented. The structure contains a fully folded C-terminal cysteine-rich domain (CRD), showing a distinct structural similarity to the resistin homotrimer, a small cytokine associated with obesity and diabetes. This structural relationship between the CRD of PCSK9 and the resistin family is not observed in primary sequence comparisons and strongly suggests a distant evolutionary link between the two molecules. This three-dimensional homology provides insight into the function of PCSK9 at the molecular level and will help to dissect the link between PCSK9 and CHD.
+The line below this paragraph, {{ABSTRACT_PUBMED_17804797}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17804797 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17804797}}
 ==About this Structure==
@@ Line 47: / Line 51: @@
 [[Category: Steroid metabolism]]
 [[Category: Zymogen]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 15:40:28 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:26:58 2008''