|
|
| Line 1: |
Line 1: |
| [[Image:2cg4.gif|left|200px]] | | {{Seed}} |
| | [[Image:2cg4.png|left|200px]] |
|
| |
|
| <!-- | | <!-- |
| Line 9: |
Line 10: |
| {{STRUCTURE_2cg4| PDB=2cg4 | SCENE= }} | | {{STRUCTURE_2cg4| PDB=2cg4 | SCENE= }} |
|
| |
|
| '''STRUCTURE OF E.COLI ASNC'''
| | ===STRUCTURE OF E.COLI ASNC=== |
|
| |
|
|
| |
|
| ==Overview==
| | <!-- |
| The Lrp/AsnC family of transcriptional regulatory proteins is found in both archaea and bacteria. Members of the family influence cellular metabolism in both a global (Lrp) and specific (AsnC) manner, often in response to exogenous amino acid effectors. In the present study we have determined both the first bacterial and the highest resolution structures for members of the family. Escherichia coli AsnC is a specific gene regulator whose activity is triggered by asparagine binding. Bacillus subtilis LrpC is a global regulator involved in chromosome condensation. Our AsnC-asparagine structure is the first for a regulator-effector complex and is revealed as an octameric disc. Key ligand recognition residues are identified together with a route for ligand access. The LrpC structure reveals a stable octamer supportive of a topological role in dynamic DNA packaging. The structures yield significant clues to the functionality of Lrp/AsnC-type regulators with respect to ligand binding and oligomerization states as well as to their role in specific and global DNA regulation. | | The line below this paragraph, {{ABSTRACT_PUBMED_16528101}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16528101 is the PubMed ID number. |
| | --> |
| | {{ABSTRACT_PUBMED_16528101}} |
|
| |
|
| ==About this Structure== | | ==About this Structure== |
| Line 39: |
Line 43: |
| [[Category: Transcription]] | | [[Category: Transcription]] |
| [[Category: Transcription regulation]] | | [[Category: Transcription regulation]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 22:03:44 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:35:20 2008'' |
