1r5m: Difference between revisions

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[[Image:1r5m.gif|left|200px]]
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[[Image:1r5m.png|left|200px]]


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{{STRUCTURE_1r5m|  PDB=1r5m  |  SCENE=  }}  
{{STRUCTURE_1r5m|  PDB=1r5m  |  SCENE=  }}  


'''Crystal Structure Of The C-Terminal WD40 Domain Of Sif2'''
===Crystal Structure Of The C-Terminal WD40 Domain Of Sif2===




==Overview==
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In Saccharomyces cerevisiae, the SIF2 gene product is an integral component of the Set3 complex (SET3C), an assembly of proteins with some homology to the human SMRT and N-CoR corepressor complexes. SET3C has histone deacetylase activity that is responsible for repressing a set of meiotic genes. We have determined the X-ray crystal structure of a 46 kDa C-terminal domain of a SET3C core protein, Sif2p to 1.55 A resolution and a crystallographic R-factor of 19.0%. This domain contains an unusual eight-bladed beta-propeller structure, which differs from other transcriptional corepressor structures such as yeast Tup1p and human groucho (Gro)/TLE1, which have only seven. We have demonstrated intact Sif2p is a tetramer and the N-terminal LisH (Lis-homology)-containing domain mediates tetramerization and interaction with another component of SET3C, Snt1p. Multiple sequence alignments indicate that a surface on the "top" of the protein is conserved among species, suggesting that it may play a common role in binding partner proteins. Since Sif2p appears to be the yeast homolog of human TBL1 and TBLR1, which function in the N-CoR/SMRT complexes, its structural and oligomeric properties are likely to be very similar.
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{{ABSTRACT_PUBMED_16051270}}


==About this Structure==
==About this Structure==
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[[Category: Transcription corepressor]]
[[Category: Transcription corepressor]]
[[Category: Wd40 repeat]]
[[Category: Wd40 repeat]]
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Revision as of 00:01, 29 July 2008

File:1r5m.png

Template:STRUCTURE 1r5m

Crystal Structure Of The C-Terminal WD40 Domain Of Sif2

Template:ABSTRACT PUBMED 16051270

About this Structure

1R5M is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The structure of Sif2p, a WD repeat protein functioning in the SET3 corepressor complex., Cerna D, Wilson DK, J Mol Biol. 2005 Aug 26;351(4):923-35. PMID:16051270

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