2rkq: Difference between revisions

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[[Image:2rkq.jpg|left|200px]]
{{Seed}}
[[Image:2rkq.png|left|200px]]


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{{STRUCTURE_2rkq|  PDB=2rkq  |  SCENE=  }}  
{{STRUCTURE_2rkq|  PDB=2rkq  |  SCENE=  }}  


'''Crystal structure of drosophila peptidoglycan recognition protein SD (PGRP-SD)'''
===Crystal structure of drosophila peptidoglycan recognition protein SD (PGRP-SD)===




==Overview==
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In Drosophila the synthesis of antimicrobial peptides in response to microbial infections is under the control of the Toll and immune deficiency (Imd) signaling pathways. The Toll signaling pathway responds mainly to Gram-positive bacterial and fungal infection while the Imd pathway mediates the response to Gram-negative bacteria. Microbial recognition upstream of Toll involves, at least in part, peptidoglycan recognition proteins (PGRPs). The sensing of Gram-positive bacteria is mediated by the pattern recognition receptors PGRP-SA and Gram-negative binding protein 1 (GNBP1) that cooperate to detect the presence of lysine-type peptidoglycan in the host. Recently it has been shown that a loss-of-function mutation in peptidoglycan recognition protein SD (PGRP-SD) severely exacerbates the PGRP-SA and GNBP1 mutant phenotypes. Here we have solved the crystal structure of PGRP-SD at 1.5A resolution. Comparison with available structures of PGRPs in complex with their peptidoglycan (PGN) ligand strongly suggests a diaminopimelic acid (DAP) specificity for PGRP-SD. This result is supported by pull-down assays with insoluble PGNs. In addition we show that Toll pathway activation after infection by DAP-type PGN containing bacteria is clearly reduced in PGRP-SD mutant flies. Our hypothesis is that the role of PGRP-SD is the recognition of DAP-type PGNs responsible for the activation of the Toll pathway by Gram-negative bacteria.
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(as it appears on PubMed at http://www.pubmed.gov), where 18304640 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18304640}}


==About this Structure==
==About this Structure==
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[[Category: Secreted]]
[[Category: Secreted]]
[[Category: Toll]]
[[Category: Toll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:13:20 2008''

Revision as of 00:13, 29 July 2008

File:2rkq.png

Template:STRUCTURE 2rkq

Crystal structure of drosophila peptidoglycan recognition protein SD (PGRP-SD)

Template:ABSTRACT PUBMED 18304640

About this Structure

2RKQ is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Crystal structure of Drosophila PGRP-SD suggests binding to DAP-type but not lysine-type peptidoglycan., Leone P, Bischoff V, Kellenberger C, Hetru C, Royet J, Roussel A, Mol Immunol. 2008 May;45(9):2521-30. Epub 2008 Mar 4. PMID:18304640

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