1w1f: Difference between revisions

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[[Image:1w1f.gif|left|200px]]
{{Seed}}
[[Image:1w1f.png|left|200px]]


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{{STRUCTURE_1w1f|  PDB=1w1f  |  SCENE=  }}  
{{STRUCTURE_1w1f|  PDB=1w1f  |  SCENE=  }}  


'''SH3 DOMAIN OF HUMAN LYN TYROSINE KINASE'''
===SH3 DOMAIN OF HUMAN LYN TYROSINE KINASE===




==Overview==
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The Src homology 3 (SH3) domain of the Src family kinase Lyn binds to the herpesviral tyrosine kinase interacting protein (Tip) more than one order of magnitude stronger than other closely related members of the Src family. In order to identify the molecular basis for high-affinity binding, the structure of free and Tip-bound Lyn-SH3 was determined by NMR spectroscopy. Tip forms additional contacts outside its classical proline-rich recognition motif and, in particular, a strictly conserved leucine (L186) of the C-terminally adjacent sequence stretch packs into a hydrophobic pocket on the Lyn surface. Although the existence of this pocket is no unique property of Lyn-SH3, Lyn is the only Src family kinase that contains an additional aromatic residue (H41) in the n-Src loop as part of this pocket. H41 covers L186 of Tip by forming tight hydrophobic contacts, and model calculations suggest that the increase in binding affinity compared with other SH3 domains can mainly be attributed to these additional interactions. These findings indicate that this pocket can mediate specificity even between otherwise closely related SH3 domains.
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(as it appears on PubMed at http://www.pubmed.gov), where 16155203 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16155203}}


==About this Structure==
==About this Structure==
1W1F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W1F OCA].  
1W1F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1W1F OCA].  


==Reference==
==Reference==
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[[Category: Signal transduction]]
[[Category: Signal transduction]]
[[Category: Tyrosine kinase]]
[[Category: Tyrosine kinase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:01:16 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:14:21 2008''

Revision as of 00:14, 29 July 2008

File:1w1f.png

Template:STRUCTURE 1w1f

SH3 DOMAIN OF HUMAN LYN TYROSINE KINASE

Template:ABSTRACT PUBMED 16155203

About this Structure

1W1F is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity., Bauer F, Schweimer K, Meiselbach H, Hoffmann S, Rosch P, Sticht H, Protein Sci. 2005 Oct;14(10):2487-98. Epub 2005 Sep 9. PMID:16155203

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