2rcu: Difference between revisions

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[[Image:2rcu.gif|left|200px]]
{{Seed}}
[[Image:2rcu.png|left|200px]]


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{{STRUCTURE_2rcu|  PDB=2rcu  |  SCENE=  }}  
{{STRUCTURE_2rcu|  PDB=2rcu  |  SCENE=  }}  


'''Crystal structure of rat carnitine palmitoyltransferase 2 in complex with r-3-(hexadecanoylamino)-4-(trimethylazaniumyl)butanoate'''
===Crystal structure of rat carnitine palmitoyltransferase 2 in complex with r-3-(hexadecanoylamino)-4-(trimethylazaniumyl)butanoate===




==Overview==
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The mitochondrial membrane-associated carnitine palmitoyltransferase system is a validated target for the treatment of type 2 diabetes mellitus. To further facilitate structure-based drug discovery, we determined the crystal structure of rat CPT-2 (rCPT-2) in complex with the substrate analogue palmitoyl-aminocarnitine at 1.8A resolution. Biochemical analyses revealed a strong effect of this compound on rCPT-2 activity and stability. Using a computational approach we examined the membrane association of rCPT-2. The protein interacts with the membrane as a functional monomer and the calculations confirm the presence of a membrane association domain that consists of layers of hydrophobic and positively charged residues.
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{{ABSTRACT_PUBMED_17585909}}


==About this Structure==
==About this Structure==
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[[Category: Transit peptide]]
[[Category: Transit peptide]]
[[Category: Transport]]
[[Category: Transport]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 16:39:22 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:21:42 2008''

Revision as of 00:21, 29 July 2008

File:2rcu.png

Template:STRUCTURE 2rcu

Crystal structure of rat carnitine palmitoyltransferase 2 in complex with r-3-(hexadecanoylamino)-4-(trimethylazaniumyl)butanoate

Template:ABSTRACT PUBMED 17585909

About this Structure

2RCU is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Carnitine palmitoyltransferase 2: analysis of membrane association and complex structure with a substrate analog., Rufer AC, Lomize A, Benz J, Chomienne O, Thoma R, Hennig M, FEBS Lett. 2007 Jul 10;581(17):3247-52. Epub 2007 Jun 8. PMID:17585909

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