2ai2: Difference between revisions

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[[Image:2ai2.gif|left|200px]]
{{Seed}}
[[Image:2ai2.png|left|200px]]


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{{STRUCTURE_2ai2|  PDB=2ai2  |  SCENE=  }}  
{{STRUCTURE_2ai2|  PDB=2ai2  |  SCENE=  }}  


'''Purine nucleoside phosphorylase from calf spleen'''
===Purine nucleoside phosphorylase from calf spleen===




==Overview==
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In an effort to develop potent multisubstrate-analog inhibitors of purine nucleoside phosphorylase (PNP), three nucleoside phosphonates were designed utilizing structural information from the previously reported structures of complexes of bovine PNP with substrates and products. The nucleoside phosphonates contain an acetal linkage at the O2' and O3' positions and a two-C-atom spacer between the ribose and phosphate moieties. The linkage enables the compounds to simultaneously occupy the purine-, ribose- and phosphate-binding sites. The chemical syntheses, inhibition profiles and structural characterization of these novel multisubstrate analog inhibitors with bovine PNP are described.
The line below this paragraph, {{ABSTRACT_PUBMED_16239721}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16239721 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16239721}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase., Toms AV, Wang W, Li Y, Ganem B, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2005 Nov;61(Pt 11):1449-58. Epub 2005, Oct 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16239721 16239721]
Novel multisubstrate inhibitors of mammalian purine nucleoside phosphorylase., Toms AV, Wang W, Li Y, Ganem B, Ealick SE, Acta Crystallogr D Biol Crystallogr. 2005 Nov;61(Pt 11):1449-58. Epub 2005, Oct 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16239721 16239721]
Calf spleen purine nucleoside phosphorylase complexed with substrates and substrate analogues., Mao C, Cook WJ, Zhou M, Federov AA, Almo SC, Ealick SE, Biochemistry. 1998 May 19;37(20):7135-46. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9585525 9585525]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Purine-nucleoside phosphorylase]]
[[Category: Purine-nucleoside phosphorylase]]
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[[Category: Multisubstrate analog inhibitor]]
[[Category: Multisubstrate analog inhibitor]]
[[Category: Purine nucleoside phosphorylase]]
[[Category: Purine nucleoside phosphorylase]]
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