1ow3: Difference between revisions

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[[Image:1ow3.~~jpg~~|left|200px]]

[[Image:1ow3.png|left|200px]]

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~~'''~~Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP~~'''~~

===Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP===

~~==Overview==~~

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The formation of complexes between small G proteins and certain of their effectors can be facilitated by aluminum fluorides. Solution studies suggest that magnesium may be able to replace aluminum in such complexes. We have determined the ~~crystal structure of RhoA.GDP bound~~ to ~~RhoGAP in~~ the ~~presence of Mg(2+) and F~~(~~-) but without Al(3+)~~. ~~The metallofluoride adopts a trigonal planar arrangement instead of the square planar structure of AlF(4)(-)~~. ~~We have confirmed that these crystals contain magnesium and not aluminum by proton-induced X-ray emission spectroscopy. The structure adopted by GDP.MgF(-~~) ~~possesses~~ the ~~stereochemistry and approximate charge expected for the transition state~~. ~~We suggest that MgF3(~~-~~) may be the reagent of choice for studying phosphoryl transfer reactions.~~

The line below this paragraph, {{ABSTRACT_PUBMED_11927263}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11927263 is the PubMed ID number.

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==About this Structure==

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[[Category: Gtpase]]

[[Category: Transition state]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 04~~:20:50 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:22:54 2008''

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-[[Image:1ow3.jpg|left|200px]]
+{{Seed}}
+[[Image:1ow3.png|left|200px]]
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 {{STRUCTURE_1ow3|  PDB=1ow3  |  SCENE=  }}
-'''Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP'''
+===Crystal Structure of RhoA.GDP.MgF3-in Complex with RhoGAP===
-==Overview==
+<!--
-The formation of complexes between small G proteins and certain of their effectors can be facilitated by aluminum fluorides. Solution studies suggest that magnesium may be able to replace aluminum in such complexes. We have determined the crystal structure of RhoA.GDP bound to RhoGAP in the presence of Mg(2+) and F(-) but without Al(3+). The metallofluoride adopts a trigonal planar arrangement instead of the square planar structure of AlF(4)(-). We have confirmed that these crystals contain magnesium and not aluminum by proton-induced X-ray emission spectroscopy. The structure adopted by GDP.MgF(-) possesses the stereochemistry and approximate charge expected for the transition state. We suggest that MgF3(-) may be the reagent of choice for studying phosphoryl transfer reactions.
+The line below this paragraph, {{ABSTRACT_PUBMED_11927263}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11927263 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11927263}}
 ==About this Structure==
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 [[Category: Gtpase]]
 [[Category: Transition state]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:20:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:22:54 2008''