1ncy: Difference between revisions

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[[Image:1ncy.jpg|left|200px]]
{{Seed}}
[[Image:1ncy.png|left|200px]]


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{{STRUCTURE_1ncy|  PDB=1ncy  |  SCENE=  }}  
{{STRUCTURE_1ncy|  PDB=1ncy  |  SCENE=  }}  


'''TROPONIN-C, COMPLEX WITH MANGANESE'''
===TROPONIN-C, COMPLEX WITH MANGANESE===




==Overview==
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The crystal structures of three metal complexes of troponin C (TnC) have been determined and refined where the two occupied structural Ca(2+) sites in the C domain have been substituted by Mn(2+), Cd(2+) and Tb(3+). The X-ray intensity data were collected to 2.1, 1.8 and 1.8 A resolution, respectively, on the three metal complexes, which are isomorphous with Ca-TnC. The three complexes have r.m.s. deviations of 0.27, 0.25 and 0.35 A, respectively, for all protein atoms, from Ca-TnC. Irrespective of the charge on the metal (+2 or +3), the occupied sites 3 and 4 exhibit a distorted pentagonal bipyramidal coordination, like Ca-TnC, with seven ligands, six from the 12-residue binding loop and the seventh from a water molecule. Mn(2+) at site 4 seems to display a longer distance to one of the carboxyl bidentate ligands representing an intermediate coordination simulating the six-coordinate Mg(2+). The carboxyl O atoms of the bidentate Glu12 are displaced on the side of the equatorial plane passing through the remaining three ligands with one O atom closer to the plane (Delta of 0.11 to 0.76 A) than the other (Delta of 0.93 to 1.38 A). The two axial ligands are an aspartic carboxyl O atom and a water molecule. The metal is displaced (0.18 to 0.56 A) towards the water facing the water channel.
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{{ABSTRACT_PUBMED_15299599}}


==About this Structure==
==About this Structure==
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[[Category: Calcium-binding protein]]
[[Category: Calcium-binding protein]]
[[Category: Muscle protein]]
[[Category: Muscle protein]]
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Revision as of 00:30, 29 July 2008

File:1ncy.png

Template:STRUCTURE 1ncy

TROPONIN-C, COMPLEX WITH MANGANESE

Template:ABSTRACT PUBMED 15299599

About this Structure

1NCY is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

X-ray structures of Mn, Cd and Tb metal complexes of troponin C., Rao ST, Satyshur KA, Greaser ML, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 1996 Sep 1;52(Pt 5):916-22. PMID:15299599

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