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[[Image:2fxp.gif|left|200px]]
{{Seed}}
[[Image:2fxp.png|left|200px]]


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{{STRUCTURE_2fxp|  PDB=2fxp  |  SCENE=  }}  
{{STRUCTURE_2fxp|  PDB=2fxp  |  SCENE=  }}  


'''Solution Structure of the SARS-Coronavirus HR2 Domain'''
===Solution Structure of the SARS-Coronavirus HR2 Domain===




==Overview==
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The envelope glycoprotein, termed the spike protein, of severe acute respiratory syndrome coronavirus (SARS-CoV) is known to mediate viral entry. Similar to other class 1 viral fusion proteins, the heptad repeat regions of SARS-CoV spike are thought to undergo conformational changes from a prefusion form to a subsequent post-fusion form that enables fusion of the viral and host membranes. Recently, the structure of a post-fusion form of SARS-CoV spike, which consists of isolated domains of heptad repeats 1 and 2 (HR1 and HR2), has been determined by x-ray crystallography. To date there is no structural information for the prefusion conformations of SARS-CoV HR1 and HR2. In this work we present the NMR structure of the HR2 domain (residues 1141-1193) from SARS-CoV (termed S2-HR2) in the presence of the co-solvent trifluoroethanol. We find that in the absence of HR1, S2-HR2 forms a coiled coil symmetric trimer with a complex molecular mass of 18 kDa. The S2-HR2 structure, which is the first example of the prefusion form of coronavirus envelope, supports the current model of viral membrane fusion and gives insight into the design of structure-based antagonists of SARS.
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{{ABSTRACT_PUBMED_16507566}}


==About this Structure==
==About this Structure==
2FXP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXP OCA].  
2FXP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FXP OCA].  


==Reference==
==Reference==
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[[Category: Trimer]]
[[Category: Trimer]]
[[Category: Virus/viral protein complex]]
[[Category: Virus/viral protein complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:22:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:35:48 2008''

Revision as of 00:35, 29 July 2008

File:2fxp.png

Template:STRUCTURE 2fxp

Solution Structure of the SARS-Coronavirus HR2 Domain

Template:ABSTRACT PUBMED 16507566

About this Structure

2FXP is a Single protein structure of sequence from Human sars coronavirus. Full experimental information is available from OCA.

Reference

Solution structure of the severe acute respiratory syndrome-coronavirus heptad repeat 2 domain in the prefusion state., Hakansson-McReynolds S, Jiang S, Rong L, Caffrey M, J Biol Chem. 2006 Apr 28;281(17):11965-71. Epub 2006 Feb 28. PMID:16507566

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