2gp8: Difference between revisions

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[[Image:2gp8.gif|left|200px]]
{{Seed}}
[[Image:2gp8.png|left|200px]]


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{{STRUCTURE_2gp8|  PDB=2gp8  |  SCENE=  }}  
{{STRUCTURE_2gp8|  PDB=2gp8  |  SCENE=  }}  


'''NMR SOLUTION STRUCTURE OF THE COAT PROTEIN-BINDING DOMAIN OF BACTERIOPHAGE P22 SCAFFOLDING PROTEIN'''
===NMR SOLUTION STRUCTURE OF THE COAT PROTEIN-BINDING DOMAIN OF BACTERIOPHAGE P22 SCAFFOLDING PROTEIN===




==Overview==
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Scaffolding proteins are required for high fidelity assembly of most high T number dsDNA viruses such as the large bacteriophages, and the herpesvirus family. They function by transiently binding and positioning the coat protein subunits during capsid assembly. In both bacteriophage P22 and the herpesviruses the extreme scaffold C terminus is highly charged, is predicted to be an amphipathic alpha-helix, and is sufficient to bind the coat protein, suggesting a common mode of action. NMR studies show that the coat protein-binding domain of P22 scaffolding protein exhibits a helix-loop-helix motif stabilized by a hydrophobic core. One face of the motif is characterized by a high density of positive charges that could interact with the coat protein through electrostatic interactions. Results from previous studies with a truncation fragment and the observed salt sensitivity of the assembly process are explained by the NMR structure.
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{{ABSTRACT_PUBMED_10764583}}


==About this Structure==
==About this Structure==
2GP8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GP8 OCA].  
2GP8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p22 Enterobacteria phage p22]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GP8 OCA].  


==Reference==
==Reference==
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[[Category: Helix-loop-helix motif]]
[[Category: Helix-loop-helix motif]]
[[Category: Scaffolding protein]]
[[Category: Scaffolding protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:21:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:37:25 2008''

Revision as of 00:37, 29 July 2008

File:2gp8.png

Template:STRUCTURE 2gp8

NMR SOLUTION STRUCTURE OF THE COAT PROTEIN-BINDING DOMAIN OF BACTERIOPHAGE P22 SCAFFOLDING PROTEIN

Template:ABSTRACT PUBMED 10764583

About this Structure

2GP8 is a Single protein structure of sequence from Enterobacteria phage p22. Full experimental information is available from OCA.

Reference

Structure of the coat protein-binding domain of the scaffolding protein from a double-stranded DNA virus., Sun Y, Parker MH, Weigele P, Casjens S, Prevelige PE Jr, Krishna NR, J Mol Biol. 2000 Apr 14;297(5):1195-202. PMID:10764583

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