2hyd: Difference between revisions

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[[Image:2hyd.gif|left|200px]]
{{Seed}}
[[Image:2hyd.png|left|200px]]


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{{STRUCTURE_2hyd|  PDB=2hyd  |  SCENE=  }}  
{{STRUCTURE_2hyd|  PDB=2hyd  |  SCENE=  }}  


'''Multidrug ABC transporter SAV1866'''
===Multidrug ABC transporter SAV1866===




==Overview==
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Multidrug transporters of the ABC family facilitate the export of diverse cytotoxic drugs across cell membranes. This is clinically relevant, as tumour cells may become resistant to agents used in chemotherapy. To understand the molecular basis of this process, we have determined the 3.0 A crystal structure of a bacterial ABC transporter (Sav1866) from Staphylococcus aureus. The homodimeric protein consists of 12 transmembrane helices in an arrangement that is consistent with cross-linking studies and electron microscopic imaging of the human multidrug resistance protein MDR1, but critically different from that reported for the bacterial lipid flippase MsbA. The observed, outward-facing conformation reflects the ATP-bound state, with the two nucleotide-binding domains in close contact and the two transmembrane domains forming a central cavity--presumably the drug translocation pathway--that is shielded from the inner leaflet of the lipid bilayer and from the cytoplasm, but exposed to the outer leaflet and the extracellular space.
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{{ABSTRACT_PUBMED_16943773}}


==About this Structure==
==About this Structure==
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[[Category: Locher, K P.]]
[[Category: Locher, K P.]]
[[Category: Transport protein]]
[[Category: Transport protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 06:51:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:45:32 2008''

Revision as of 00:45, 29 July 2008

File:2hyd.png


Drag the structure with the mouse to rotate
2hyd, resolution 3.00Å (default scene)
Ligands: ADP, NA
Gene: SAV1866 (Staphylococcus aureus)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Multidrug ABC transporter SAV1866

Template:ABSTRACT PUBMED 16943773

About this Structure

2HYD is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structure of a bacterial multidrug ABC transporter., Dawson RJ, Locher KP, Nature. 2006 Sep 14;443(7108):180-5. Epub 2006 Aug 30. PMID:16943773

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