2nv6: Difference between revisions

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[[Image:2nv6.gif|left|200px]]
{{Seed}}
[[Image:2nv6.png|left|200px]]


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{{STRUCTURE_2nv6|  PDB=2nv6  |  SCENE=  }}  
{{STRUCTURE_2nv6|  PDB=2nv6  |  SCENE=  }}  


'''Mycobacterium tuberculosis InhA (S94A) bound with INH-NAD adduct'''
===Mycobacterium tuberculosis InhA (S94A) bound with INH-NAD adduct===




==Overview==
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Isoniazid is one of the most effective antituberculosis drugs, yet its precise mechanism of action is still controversial. Using specialized linkage transduction, a single point mutation allele (S94A) within the putative target gene inhA was transferred in Mycobacterium tuberculosis. The inhA(S94A) allele was sufficient to confer clinically relevant levels of resistance to isoniazid killing and inhibition of mycolic acid biosynthesis. This resistance correlated with the decreased binding of the INH-NAD inhibitor to InhA, as shown by enzymatic and X-ray crystallographic analyses, and establishes InhA as the primary target of isoniazid action in M. tuberculosis.
The line below this paragraph, {{ABSTRACT_PUBMED_16906155}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16906155 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16906155}}


==About this Structure==
==About this Structure==
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[[Category: S94a]]
[[Category: S94a]]
[[Category: Tuberculosis]]
[[Category: Tuberculosis]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 09:56:49 2008''
 
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