2b07: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
No edit summary
OCA (talk | contribs)
No edit summary
Line 1: Line 1:
[[Image:2b07.gif|left|200px]]
{{Seed}}
[[Image:2b07.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2b07|  PDB=2b07  |  SCENE=  }}  
{{STRUCTURE_2b07|  PDB=2b07  |  SCENE=  }}  


'''Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.'''
===Crystal structure of PTP1B with Tricyclic Thiophene inhibitor.===




==Overview==
<!--
A novel pyridothiophene inhibitor of PTP1B was discovered by rational screening of phosphotyrosine mimics at high micromolar concentrations. The potency of this lead compound has been improved significantly by medicinal chemistry guided by X-ray crystallography and molecular modeling. Excellent consistency has been observed between structure-activity relationships and structural information from PTP1B-inhibitor complexes.
The line below this paragraph, {{ABSTRACT_PUBMED_16303309}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16303309 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16303309}}


==About this Structure==
==About this Structure==
Line 41: Line 45:
[[Category: Protein tyrosine phosphatase]]
[[Category: Protein tyrosine phosphatase]]
[[Category: Tricyclic thiophene]]
[[Category: Tricyclic thiophene]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 19:41:25 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:59:47 2008''