1zlb: Difference between revisions

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[[Image:1zlb.gif|left|200px]]
{{Seed}}
[[Image:1zlb.png|left|200px]]


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{{STRUCTURE_1zlb|  PDB=1zlb  |  SCENE=  }}  
{{STRUCTURE_1zlb|  PDB=1zlb  |  SCENE=  }}  


'''Crystal structure of catalytically-active phospholipase A2 in the absence of calcium'''
===Crystal structure of catalytically-active phospholipase A2 in the absence of calcium===




==Overview==
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The electrophile Ca(2+) is an essential multifunctional co-factor in the phospholipase A(2) mediated hydrolysis of phospholipids. Crystal structures of an acidic phospholipase A(2) from the venom of Bothrops jararacussu have been determined both in the Ca(2+) free and bound states at 0.97 and 1.60 A resolutions, respectively. In the Ca(2+) bound state, the Ca(2+) ion is penta-coordinated by a distorted pyramidal cage of oxygen and nitrogen atoms that is significantly different to that observed in structures of other Group I/II phospholipases A(2). In the absence of Ca(2+), a water molecule occupies the position of the Ca(2+) ion and the side chain of Asp49 and the calcium-binding loop adopts a different conformation.
The line below this paragraph, {{ABSTRACT_PUBMED_16376474}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16376474 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16376474}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Insights into metal ion binding in phospholipases A2: ultra high-resolution crystal structures of an acidic phospholipase A2 in the Ca2+ free and bound states., Murakami MT, Gabdoulkhakov A, Genov N, Cintra AC, Betzel C, Arni RK, Biochimie. 2006 May;88(5):543-9. Epub 2005 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16376474 16376474]
Insights into metal ion binding in phospholipases A2: ultra high-resolution crystal structures of an acidic phospholipase A2 in the Ca2+ free and bound states., Murakami MT, Gabdoulkhakov A, Genov N, Cintra AC, Betzel C, Arni RK, Biochimie. 2006 May;88(5):543-9. Epub 2005 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16376474 16376474]
Crystallization and high-resolution X-ray diffraction data collection of an Asp49 PLA2 from Bothrops jararacussu venom both in the presence and absence of Ca2+ ions., Murakami MT, Michelan-Duarte S, Cintra AC, Arni RK, Biochim Biophys Acta. 2004 Dec 1;1703(1):79-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15588705 15588705]
[[Category: Bothrops jararacussu]]
[[Category: Bothrops jararacussu]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Snake venom]]
[[Category: Snake venom]]
[[Category: Toxin]]
[[Category: Toxin]]
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