1psk: Difference between revisions

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[[Image:1psk.gif|left|200px]]
{{Seed}}
[[Image:1psk.png|left|200px]]


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{{STRUCTURE_1psk|  PDB=1psk  |  SCENE=  }}  
{{STRUCTURE_1psk|  PDB=1psk  |  SCENE=  }}  


'''THE CRYSTAL STRUCTURE OF AN FAB FRAGMENT THAT BINDS TO THE MELANOMA-ASSOCIATED GD2 GANGLIOSIDE'''
===THE CRYSTAL STRUCTURE OF AN FAB FRAGMENT THAT BINDS TO THE MELANOMA-ASSOCIATED GD2 GANGLIOSIDE===




==Overview==
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The GD2 ganglioside is a cell-surface component that appears on the surface of metastatic melanoma cells and is a marker for the progression of the disease. The ME36.1 monoclonal antibody binds to the GD2 ganglioside and has shown potential as a therapeutic antibody. ME36.1 is a possible alternative therapy to radiation, which is often ineffective in late-stage melanoma. The crystal structure of the Fab fragment of ME36.1 has been determined using molecular replacement and refined to an R factor of 20.4% at 2.8 A resolution. The model has good geometry with root-mean-square deviations of 0.008 A from ideal bond lengths and 1.7 degrees from ideal bond angles. The crystal structure of the ME36.1 Fab shows that its complementarity determining region forms a groove-shaped binding site rather than the pocket-type observed in other sugar binding Fabs. Molecular modeling has placed a four-residue sugar, representative of GD2, in the antigen binding site. The GD2 sugar moiety is stabilized by a network of hydrogen bonds that define the specificity of ME36.1 toward its antigen.
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{{ABSTRACT_PUBMED_9216084}}


==About this Structure==
==About this Structure==
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[[Category: Immunoglobulin]]
[[Category: Immunoglobulin]]
[[Category: Melanoma]]
[[Category: Melanoma]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:26:22 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:30:10 2008''

Revision as of 01:30, 29 July 2008

File:1psk.png

Template:STRUCTURE 1psk

THE CRYSTAL STRUCTURE OF AN FAB FRAGMENT THAT BINDS TO THE MELANOMA-ASSOCIATED GD2 GANGLIOSIDE

Template:ABSTRACT PUBMED 9216084

About this Structure

1PSK is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

The crystal structure of a Fab fragment to the melanoma-associated GD2 ganglioside., Pichla SL, Murali R, Burnett RM, J Struct Biol. 1997 Jun;119(1):6-16. PMID:9216084

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