2efz: Difference between revisions

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[[Image:2efz.jpg|left|200px]]
{{Seed}}
[[Image:2efz.png|left|200px]]


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{{STRUCTURE_2efz|  PDB=2efz  |  SCENE=  }}  
{{STRUCTURE_2efz|  PDB=2efz  |  SCENE=  }}  


'''Solution Structure of an M-1 Conotoxin with a novel disulfide linkage'''
===Solution Structure of an M-1 Conotoxin with a novel disulfide linkage===




==Overview==
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The M-superfamily of conotoxins has a typical Cys framework (-CC-C-C-CC-), and is one of the eight major superfamilies found in the venom of the cone snail. Depending on the number of residues located in the last Cys loop (between Cys4 and Cys5), the M-superfamily family can be divided into four branches, namely M-1, -2, -3 and -4. Recently, two M-1 branch conotoxins (mr3e and tx3a) have been reported to possess a new disulfide bond arrangement between Cys1 and Cys5, Cys2 and Cys4, and Cys3 and Cys6, which is different from those seen in the M-2 and M-4 branches. Here we report the 3D structure of mr3e determined by 2D (1)H NMR in aqueous solution. Twenty converged structures of this peptide were obtained on the basis of 190 distance constraints obtained from NOE connectivities, as well as six varphi dihedral angle, three hydrogen bond, and three disulfide bond constraints. The rmsd values about the averaged coordinates of the backbone atoms were 0.43 +/- 0.19 A. Although mr3e has the same Cys arrangement as M-2 and M-4 conotoxins, it adopts a distinctive backbone conformation with the overall molecule resembling a 'flying bird'. Thus, different disulfide linkages may be employed by conotoxins with the same Cys framework to result in a more diversified backbone scaffold.
The line below this paragraph, {{ABSTRACT_PUBMED_17437523}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17437523 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17437523}}


==About this Structure==
==About this Structure==
2EFZ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFZ OCA].  
2EFZ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EFZ OCA].  


==Reference==
==Reference==
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[[Category: Huang, F J.]]
[[Category: Huang, F J.]]
[[Category: M-conotoxin mr3e]]
[[Category: M-conotoxin mr3e]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 02:29:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:40:47 2008''

Revision as of 01:40, 29 July 2008

File:2efz.png

Template:STRUCTURE 2efz

Solution Structure of an M-1 Conotoxin with a novel disulfide linkage

Template:ABSTRACT PUBMED 17437523

About this Structure

2EFZ is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of an M-1 conotoxin with a novel disulfide linkage., Du WH, Han YH, Huang FJ, Li J, Chi CW, Fang WH, FEBS J. 2007 May;274(10):2596-602. Epub 2007 Apr 16. PMID:17437523

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