1u8a: Difference between revisions

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[[Image:1u8a.png|left|200px]]

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~~'''~~Crystal Structure of Mycobacterium Tuberculosis Shikimate Kinase in Complex with Shikimate and ADP at 2.15 Angstrom Resolution~~'''~~

===Crystal Structure of Mycobacterium Tuberculosis Shikimate Kinase in Complex with Shikimate and ADP at 2.15 Angstrom Resolution===

~~==Overview==~~

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The ~~X-ray crystal structure of Mycobacterium tuberculosis shikimate kinase~~ (~~SK) with bound shikimate and adenosine diphosphate (ADP) has been determined to a resolution of 2~~.~~15 A~~. The binding of shikimate in a shikimate kinase crystal structure has not previously been reported. The substrate binds in a pocket lined with hydrophobic residues and interacts with several highly conserved charged residues including Asp34, ~~Arg58, Glu61 and Arg136 which project into~~ the ~~cavity~~. ~~Comparisons of our ternary SK~~-~~ADP~~-shikimate complex with an earlier binary SK-ADP complex show that conformational changes occur on shikimate binding with the substrate-binding domain rotating by 10 degrees. Detailed knowledge of shikimate binding is an important step in the design of inhibitors of SK, which have potential as novel anti-tuberculosis agents.

The line below this paragraph, {{ABSTRACT_PUBMED_15358538}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15358538 is the PubMed ID number.

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==About this Structure==

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[[Category: Shikimate pathway]]

[[Category: X-ray crystallography]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 10~~:53:15 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:41:15 2008''

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-[[Image:1u8a.gif|left|200px]]
+{{Seed}}
+[[Image:1u8a.png|left|200px]]
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 {{STRUCTURE_1u8a|  PDB=1u8a  |  SCENE=  }}
-'''Crystal Structure of Mycobacterium Tuberculosis Shikimate Kinase in Complex with Shikimate and ADP at 2.15 Angstrom Resolution'''
+===Crystal Structure of Mycobacterium Tuberculosis Shikimate Kinase in Complex with Shikimate and ADP at 2.15 Angstrom Resolution===
-==Overview==
+<!--
-The X-ray crystal structure of Mycobacterium tuberculosis shikimate kinase (SK) with bound shikimate and adenosine diphosphate (ADP) has been determined to a resolution of 2.15 A. The binding of shikimate in a shikimate kinase crystal structure has not previously been reported. The substrate binds in a pocket lined with hydrophobic residues and interacts with several highly conserved charged residues including Asp34, Arg58, Glu61 and Arg136 which project into the cavity. Comparisons of our ternary SK-ADP-shikimate complex with an earlier binary SK-ADP complex show that conformational changes occur on shikimate binding with the substrate-binding domain rotating by 10 degrees. Detailed knowledge of shikimate binding is an important step in the design of inhibitors of SK, which have potential as novel anti-tuberculosis agents.
+The line below this paragraph, {{ABSTRACT_PUBMED_15358538}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15358538 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15358538}}
 ==About this Structure==
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 [[Category: Shikimate pathway]]
 [[Category: X-ray crystallography]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:53:15 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:41:15 2008''