2pff: Difference between revisions

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[[Image:2pff.jpg|left|200px]]
{{Seed}}
[[Image:2pff.png|left|200px]]


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{{STRUCTURE_2pff|  PDB=2pff  |  SCENE=  }}  
{{STRUCTURE_2pff|  PDB=2pff  |  SCENE=  }}  


'''Structural Insights of Yeast Fatty Acid Synthase'''
===Structural Insights of Yeast Fatty Acid Synthase===




==Overview==
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In yeast, the whole metabolic pathway for making 16- and 18-carbon fatty acids is carried out by fatty acid synthase, a 2.6 megadalton molecular-weight macromolecular assembly containing six copies of all eight catalytic centers. We have determined its crystal structure, which illuminates how this enzyme is initially activated and then carries out multiple steps of synthesis in each of six sterically isolated reaction chambers. Six of the catalytic sites are in the wall of the assembly facing an acyl carrier protein (ACP) bound to the ketoacyl synthase domain. Two-dimensional diffusion of substrates to the catalytic sites may be achieved by the electrostatically negative ACP swinging to each of the six electrostatically positive catalytic sites. The phosphopantetheinyl transferase domain lies outside the shell of the assembly, inaccessible to ACP that lies inside, suggesting that the attachment of the pantetheine arm to ACP must occur before complete assembly of the complex.
The line below this paragraph, {{ABSTRACT_PUBMED_17448991}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17448991}}


==About this Structure==
==About this Structure==
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[[Category: Fatty acid synthase]]
[[Category: Fatty acid synthase]]
[[Category: Malonyltransferase]]
[[Category: Malonyltransferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:00:10 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:42:29 2008''

Revision as of 01:42, 29 July 2008

File:2pff.png

Template:STRUCTURE 2pff

Structural Insights of Yeast Fatty Acid Synthase

Template:ABSTRACT PUBMED 17448991

About this Structure

2PFF is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together., Lomakin IB, Xiong Y, Steitz TA, Cell. 2007 Apr 20;129(2):319-32. PMID:17448991

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