1yyo: Difference between revisions

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[[Image:1yyo.gif|left|200px]]
{{Seed}}
[[Image:1yyo.png|left|200px]]


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{{STRUCTURE_1yyo|  PDB=1yyo  |  SCENE=  }}  
{{STRUCTURE_1yyo|  PDB=1yyo  |  SCENE=  }}  


'''Crystal structure of RNase III mutant E110K from Aquifex aeolicus complexed with double-stranded RNA at 2.9-Angstrom Resolution'''
===Crystal structure of RNase III mutant E110K from Aquifex aeolicus complexed with double-stranded RNA at 2.9-Angstrom Resolution===




==Overview==
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Bacterial ribonuclease III (RNase III) can affect RNA structure and gene expression in either of two ways: as a processing enzyme that cleaves double-stranded (ds) RNA, or as a binding protein that binds but does not cleave dsRNA. We previously proposed a model of the catalytic complex of RNase III with dsRNA based on three crystal structures, including the endonuclease domain of RNase III with and without bound metal ions and a dsRNA binding protein complexed with dsRNA. We also reported a noncatalytic assembly observed in the crystal structure of an RNase III mutant, which binds but does not cleave dsRNA, complexed with dsRNA. We hypothesize that the RNase III*dsRNA complex can exist in two functional forms, a catalytic complex and a noncatalytic assembly, and that in between the two forms there may be intermediate states. Here, we present four crystal structures of RNase III complexed with dsRNA, representing possible intermediates.
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{{ABSTRACT_PUBMED_16216575}}


==About this Structure==
==About this Structure==
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[[Category: Ribonuclease iii]]
[[Category: Ribonuclease iii]]
[[Category: Rna interference]]
[[Category: Rna interference]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:58:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:50:26 2008''

Revision as of 01:50, 29 July 2008

File:1yyo.png

Template:STRUCTURE 1yyo

Crystal structure of RNase III mutant E110K from Aquifex aeolicus complexed with double-stranded RNA at 2.9-Angstrom Resolution

Template:ABSTRACT PUBMED 16216575

About this Structure

1YYO is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Intermediate states of ribonuclease III in complex with double-stranded RNA., Gan J, Tropea JE, Austin BP, Court DL, Waugh DS, Ji X, Structure. 2005 Oct;13(10):1435-42. PMID:16216575

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