331d: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
[[Image:331d.gif|left|200px]]
{{Seed}}
[[Image:331d.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_331d|  PDB=331d  |  SCENE=  }}  
{{STRUCTURE_331d|  PDB=331d  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S'''
===CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S===




==Overview==
<!--  
The crystal structure of the DNA heptamer d(GCGCGCG) has been solved at 1.65 A resolution by the molecular replacement method and refined to an R-value of 0.184 for 3598 reflections. The heptamer forms a Z-DNA d(CGCGCG)2 with 5'-overhang G residues instead of an A-DNA d(GCGCGC)2 with 3'-overhang G residues. The overhang G residues from parallel strands of two adjacent duplexes form a trans reverse Hoogsteen G x G basepair that stacks on the six Z-DNA basepairs to produce a pseudocontinuous helix. The reverse Hoogsteen G x G basepair is unusual in that the displacement of one G base relative to the other allows them to participate in a bifurcated (G1)N2 . . . N7(G8) and an enhanced (G8)C8-H . . . O6(G1) hydrogen bond, in addition to the two usual hydrogen bonds. The 5'-overhang G residues are anti and C2'-endo while the 3'-terminal G residues are syn and C2'-endo. The conformations of both G residues are different from the syn/C3'-endo for the guanosine in a standard Z-DNA. The two cobalt hexammine ions bind to the phosphate groups in both GpC and CpG steps in Z(I) and Z(II) conformations. The water structure motif is similar to the other Z-DNA structures.
The line below this paragraph, {{ABSTRACT_PUBMED_9284322}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9284322 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_9284322}}


==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Overhanging base]]
[[Category: Overhanging base]]
[[Category: Z-dna]]
[[Category: Z-dna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:16:05 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:55:31 2008''

Revision as of 01:55, 29 July 2008

File:331d.png

Template:STRUCTURE 331d

CRYSTAL STRUCTURE OF D(GCGCGCG) WITH 5'-OVERHANG G'S

Template:ABSTRACT PUBMED 9284322

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of d(GCGCGCG) with 5'-overhang G residues., Pan B, Ban C, Wahl MC, Sundaralingam M, Biophys J. 1997 Sep;73(3):1553-61. PMID:9284322

Page seeded by OCA on Tue Jul 29 04:55:31 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=331d&oldid=727872"