2ilk: Difference between revisions

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[[Image:2ilk.jpg|left|200px]]
{{Seed}}
[[Image:2ilk.png|left|200px]]


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{{STRUCTURE_2ilk|  PDB=2ilk  |  SCENE=  }}  
{{STRUCTURE_2ilk|  PDB=2ilk  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-10 AT 1.6 ANGSTROMS RESOLUTION'''
===CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-10 AT 1.6 ANGSTROMS RESOLUTION===




==Overview==
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The crystal structure of human interleukin-10 (IL-10) was refined at 1.6 A resolution against X-ray diffraction data collected at 100 K with the use of synchrotron radiation. Although similar to the IL-10 structure determined previously at room temperature, this low-temperature IL-10 structure contains, in addition, four N-terminal residues, three sulfate anions, and 175 extra water molecules. Whereas the main-chain conformation is preserved, about 30% of the side chains, most of them on the protein surface, assume different conformations. A computer model of a complex of IL-10 with its two soluble receptors was generated based on the topological similarity of IL-10 to interferon-gamma. The contact region between the cytokine and each receptor shows excellent complementarity of polar and hydrophobic interactions, suggesting that the model is generally correct and should be useful in guiding mutagenesis experiments.
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{{ABSTRACT_PUBMED_8897595}}


==About this Structure==
==About this Structure==
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[[Category: Zdanov, A.]]
[[Category: Zdanov, A.]]
[[Category: Cytokine]]
[[Category: Cytokine]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:37:44 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:56:11 2008''

Revision as of 01:56, 29 July 2008

File:2ilk.png

Template:STRUCTURE 2ilk

CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-10 AT 1.6 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 8897595

About this Structure

2ILK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human interleukin-10 at 1.6 A resolution and a model of a complex with its soluble receptor., Zdanov A, Schalk-Hihi C, Wlodawer A, Protein Sci. 1996 Oct;5(10):1955-62. PMID:8897595

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