1r1b: Difference between revisions

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[[Image:1r1b.jpg|left|200px]]
{{Seed}}
[[Image:1r1b.png|left|200px]]


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{{STRUCTURE_1r1b|  PDB=1r1b  |  SCENE=  }}  
{{STRUCTURE_1r1b|  PDB=1r1b  |  SCENE=  }}  


'''EPRS SECOND REPEATED ELEMENT, NMR, MINIMIZED AVERAGE STRUCTURE'''
===EPRS SECOND REPEATED ELEMENT, NMR, MINIMIZED AVERAGE STRUCTURE===




==Overview==
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Aminoacyl-tRNA synthetases of higher eukaryotes possess polypeptide extensions in contrast to their prokaryotic counterparts. These extra domains of poorly understood function are believed to be involved in protein-protein or protein-RNA interactions. Here we showed by gel retardation and filter binding experiments that the repeated units that build the linker region of the bifunctional glutamyl-prolyl-tRNA synthetase had a general RNA-binding capacity. The solution structure of one of these repeated motifs was also solved by NMR spectroscopy. One repeat is built around an antiparallel coiled-coil. Strikingly, the conserved lysine and arginine residues form a basic patch on one side of the structure, presenting a suitable docking surface for nucleic acids. Therefore, this repeated motif may represent a novel type of general RNA-binding domain appended to eukaryotic aminoacyl-tRNA synthetases to serve as a cis-acting tRNA-binding cofactor.
The line below this paragraph, {{ABSTRACT_PUBMED_10654942}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10654942 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10654942}}


==About this Structure==
==About this Structure==
1R1B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1B OCA].  
1R1B is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R1B OCA].  


==Reference==
==Reference==
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[[Category: Mirande, M.]]
[[Category: Mirande, M.]]
[[Category: Protein transcription]]
[[Category: Protein transcription]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:57:22 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:07:39 2008''

Revision as of 02:07, 29 July 2008

File:1r1b.png

Template:STRUCTURE 1r1b

EPRS SECOND REPEATED ELEMENT, NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 10654942

About this Structure

1R1B is a Single protein structure of sequence from Cricetulus griseus. Full experimental information is available from OCA.

Reference

A recurrent RNA-binding domain is appended to eukaryotic aminoacyl-tRNA synthetases., Cahuzac B, Berthonneau E, Birlirakis N, Guittet E, Mirande M, EMBO J. 2000 Feb 1;19(3):445-52. PMID:10654942

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