2ihm: Difference between revisions

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[[Image:2ihm.gif|left|200px]]
{{Seed}}
[[Image:2ihm.png|left|200px]]


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{{STRUCTURE_2ihm|  PDB=2ihm  |  SCENE=  }}  
{{STRUCTURE_2ihm|  PDB=2ihm  |  SCENE=  }}  


'''Polymerase mu in ternary complex with gapped 11mer DNA duplex and bound incoming nucleotide'''
===Polymerase mu in ternary complex with gapped 11mer DNA duplex and bound incoming nucleotide===




==Overview==
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DNA polymerase mu (Pol mu) is a family X enzyme with unique substrate specificity that contributes to its specialized role in nonhomologous DNA end joining (NHEJ). To investigate Pol mu's unusual substrate specificity, we describe the 2.4 A crystal structure of the polymerase domain of murine Pol mu bound to gapped DNA with a correct dNTP at the active site. This structure reveals substrate interactions with side chains in Pol mu that differ from other family X members. For example, a single amino acid substitution, H329A, has little effect on template-dependent synthesis by Pol mu from a paired primer terminus, but it reduces both template-independent and template-dependent synthesis during NHEJ of intermediates whose 3' ends lack complementary template strand nucleotides. These results provide insight into the substrate specificity and differing functions of four closely related mammalian family X DNA polymerases.
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{{ABSTRACT_PUBMED_17159995}}


==About this Structure==
==About this Structure==
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[[Category: Helix-turn-helix]]
[[Category: Helix-turn-helix]]
[[Category: Polymerase]]
[[Category: Polymerase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:30:49 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:34:14 2008''

Revision as of 02:34, 29 July 2008

File:2ihm.png

Template:STRUCTURE 2ihm

Polymerase mu in ternary complex with gapped 11mer DNA duplex and bound incoming nucleotide

Template:ABSTRACT PUBMED 17159995

About this Structure

2IHM is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural insight into the substrate specificity of DNA Polymerase mu., Moon AF, Garcia-Diaz M, Bebenek K, Davis BJ, Zhong X, Ramsden DA, Kunkel TA, Pedersen LC, Nat Struct Mol Biol. 2007 Jan;14(1):45-53. Epub 2006 Dec 10. PMID:17159995

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