1sj6: Difference between revisions

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[[Image:1sj6.gif|left|200px]]
{{Seed}}
[[Image:1sj6.png|left|200px]]


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{{STRUCTURE_1sj6|  PDB=1sj6  |  SCENE=  }}  
{{STRUCTURE_1sj6|  PDB=1sj6  |  SCENE=  }}  


'''NMR Structure and Regulated Expression in APL Cell of Human SH3BGRL3'''
===NMR Structure and Regulated Expression in APL Cell of Human SH3BGRL3===




==Overview==
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SH3 domain binding glutamic acid-rich protein like 3 (SH3BGRL3) is the new member of thioredoxin (TRX) super family, whose posttranslational modified form was identified as tumor necrosis factor alpha (TNF-alpha) inhibitory protein, TIP-B1. In this paper, we determined its solution structure by multi-dimensional nuclear magnetic resonance spectroscopy. The overall structure of human SH3BGRL3 conformed to a TRX-like fold. To understand its function in vivo, the upregulated expression in acute promyelocytic leukemia cell line NB4 at both mRNA and protein level was elucidated. Immunofluorescence and immunohistochemistry staining with monoclonal antibody against SH3BGRL3 demonstrated that it was a cytoplasmic protein in both NB4 cell and human tissues. These results, as a whole, indicate that SH3BGRL3 may function as a regulator in all-trans retinoic acid-induced pathway.
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{{ABSTRACT_PUBMED_15907482}}


==About this Structure==
==About this Structure==
1SJ6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJ6 OCA].  
1SJ6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SJ6 OCA].  


==Reference==
==Reference==
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[[Category: Nuclear protein]]
[[Category: Nuclear protein]]
[[Category: Thioredoxin]]
[[Category: Thioredoxin]]
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