1rw3: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:1rw3.gif|left|200px]]
{{Seed}}
[[Image:1rw3.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1rw3|  PDB=1rw3  |  SCENE=  }}  
{{STRUCTURE_1rw3|  PDB=1rw3  |  SCENE=  }}  


'''The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus'''
===The crystal structure of the monomeric reverse transcriptase from Moloney murine leukemia virus===




==Overview==
<!--  
Reverse transcriptases (RTs) are multidomain enzymes of variable architecture that couple both RNA- and DNA-directed DNA polymerase activities with an RNase H activity specific for an RNA:DNA hybrid in order to replicate the single-stranded RNA genome of the retrovirus. Previous structural work has been reported for the heterodimeric HIV-1 and HIV-2 RTs. We now report the first crystal structure of the full-length Moloney murine leukemia virus (MMLV) RT at 3.0 A resolution. The structure reveals a clamp-shaped molecule resulting from the relative positions of the thumb, connection, and RNase H domains that is strikingly different from the HIV-1 RT and provides the first example of a monomeric reverse transcriptase. A comparative analysis with related DNA polymerases suggests a unique trajectory for the template-primer exiting the polymerase active site and provides insights regarding processive DNA synthesis by MMLV RT.
The line below this paragraph, {{ABSTRACT_PUBMED_15130474}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15130474 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_15130474}}


==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Reverse transcriptase]]
[[Category: Reverse transcriptase]]
[[Category: Rna and dna dependent dna polymerase]]
[[Category: Rna and dna dependent dna polymerase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 07:58:30 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:41:29 2008''
Retrieved from "https://proteopedia.org/1rw3"