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[[Image:1tap.gif|left|200px]]
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[[Image:1tap.png|left|200px]]


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{{STRUCTURE_1tap|  PDB=1tap  |  SCENE=  }}  
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'''NMR SOLUTION STRUCTURE OF RECOMBINANT TICK ANTICOAGULANT PROTEIN (RTAP), A FACTOR XA INHIBITOR FROM THE TICK ORNITHODOROS MOUBATA'''
===NMR SOLUTION STRUCTURE OF RECOMBINANT TICK ANTICOAGULANT PROTEIN (RTAP), A FACTOR XA INHIBITOR FROM THE TICK ORNITHODOROS MOUBATA===




==Overview==
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The solution structure of the recombinant tick anticoagulant protein (rTAP) was determined by 1H nuclear magnetic resonance (NMR) spectroscopy in aqueous solution at pH 3.6 and 36 degrees C. rTAP is a 60-residue protein functioning as a highly specific inhibitor of the coagulation protease factor Xa, which was originally isolated from the tick Ornithodoros moubata. Its regular secondary structure consists of a two-stranded antiparallel beta-sheet with residues 22-28 and 32-38, and an alpha-helix with residues 51-60. The relative orientation of these regular secondary structure elements has nearly identical counterparts in the bovine pancreatic trypsin inhibitor (BPTI). In contrast, the loop between the beta-sheet and the C-terminal alpha-helix as well as the N-terminal 20-residue segment preceding the beta-sheet adopt different three-dimensional folds in the two proteins. These observations are discussed with regard to the implication of different mechanisms of protease inhibition by rTAP and by Kunitz-type protein proteinase inhibitors.
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{{ABSTRACT_PUBMED_7925983}}


==About this Structure==
==About this Structure==
1TAP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithodoros_moubata Ornithodoros moubata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TAP OCA].  
1TAP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Ornithodoros_moubata Ornithodoros moubata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TAP OCA].  


==Reference==
==Reference==
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[[Category: Wuthrich, K.]]
[[Category: Wuthrich, K.]]
[[Category: Proteinase inhibitor]]
[[Category: Proteinase inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:44:45 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:44:44 2008''

Revision as of 02:44, 29 July 2008

File:1tap.png

Template:STRUCTURE 1tap

NMR SOLUTION STRUCTURE OF RECOMBINANT TICK ANTICOAGULANT PROTEIN (RTAP), A FACTOR XA INHIBITOR FROM THE TICK ORNITHODOROS MOUBATA

Template:ABSTRACT PUBMED 7925983

About this Structure

1TAP is a Single protein structure of sequence from Ornithodoros moubata. Full experimental information is available from OCA.

Reference

NMR solution structure of the recombinant tick anticoagulant protein (rTAP), a factor Xa inhibitor from the tick Ornithodoros moubata., Antuch W, Guntert P, Billeter M, Hawthorne T, Grossenbacher H, Wuthrich K, FEBS Lett. 1994 Sep 26;352(2):251-7. PMID:7925983

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