2d58: Difference between revisions

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[[Image:2d58.gif|left|200px]]
{{Seed}}
[[Image:2d58.png|left|200px]]


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{{STRUCTURE_2d58|  PDB=2d58  |  SCENE=  }}  
{{STRUCTURE_2d58|  PDB=2d58  |  SCENE=  }}  


'''Human microglia-specific protein Iba1'''
===Human microglia-specific protein Iba1===




==Overview==
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The ionized calcium-binding adaptor molecule 1 (Iba1) with 147 amino acid residues has been identified as a calcium-binding protein, expressed specifically in microglia/macrophages, and is expected to be a key factor in membrane ruffling, which is a typical feature of activated microglia. We have determined the crystal structure of human Iba1 in a Ca(2+)-free form and mouse Iba1 in a Ca(2+)-bound form, to a resolution of 1.9 A and 2.1 A, respectively. X-ray structures of Iba1 revealed a compact, single-domain protein with two EF-hand motifs, showing similarity in overall topology to partial structures of the classical EF-hand proteins troponin C and calmodulin. In mouse Iba1, the second EF-hand contains a bound Ca(2+), but the first EF-hand does not, which is often the case in S100 proteins, suggesting that Iba1 has S100 protein-like EF-hands. The molecular conformational change induced by Ca(2+)-binding of Iba1 is different from that found in the classical EF-hand proteins and/or S100 proteins, which demonstrates that Iba1 has an unique molecular switching mechanism dependent on Ca(2+)-binding, to interact with target molecules.
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{{ABSTRACT_PUBMED_17011575}}


==About this Structure==
==About this Structure==
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[[Category: Kamitori, S.]]
[[Category: Kamitori, S.]]
[[Category: Ef-hand]]
[[Category: Ef-hand]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 23:43:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:46:15 2008''

Revision as of 02:46, 29 July 2008

File:2d58.png

Template:STRUCTURE 2d58

Human microglia-specific protein Iba1

Template:ABSTRACT PUBMED 17011575

About this Structure

2D58 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding., Yamada M, Ohsawa K, Imai Y, Kohsaka S, Kamitori S, J Mol Biol. 2006 Dec 1;364(3):449-57. Epub 2006 Sep 15. PMID:17011575

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