2pna: Difference between revisions

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[[Image:2pna.gif|left|200px]]
{{Seed}}
[[Image:2pna.png|left|200px]]


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{{STRUCTURE_2pna|  PDB=2pna  |  SCENE=  }}  
{{STRUCTURE_2pna|  PDB=2pna  |  SCENE=  }}  


'''STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE'''
===STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE===




==Overview==
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Receptor protein-tyrosine kinases, through phosphorylation of specific tyrosine residues, generate high-affinity binding sites which direct assembly of multienzyme signalling complexes. Many of these signalling proteins, including phospholipase C gamma, GTPase-activating protein and phosphatidylinositol-3-OH kinase, contain src-homology 2 (SH2) domains, which bind with high affinity and specificity to tyrosine-phosphorylated sequences. The critical role played by SH2 domains in signalling has been highlighted by recent studies showing that mutation of specific phosphorylation sites on the platelet-derived growth factor receptor impair its association with phosphatidylinositol-3-OH kinase, preventing growth factor-induced mitogenesis. Here we report the solution structure of an isolated SH2 domain from the 85K regulatory subunit of phosphatidylinositol-3-OH kinase, determined using multidimensional nuclear magnetic resonance spectroscopy. The structure is characterized by a central region of beta-sheet flanked by two alpha-helices, with a highly flexible loop close to functionally important residues previously identified by site-directed mutagenesis.
The line below this paragraph, {{ABSTRACT_PUBMED_1323062}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 1323062 is the PubMed ID number.
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{{ABSTRACT_PUBMED_1323062}}


==About this Structure==
==About this Structure==
2PNA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNA OCA].  
2PNA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PNA OCA].  


==Reference==
==Reference==
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[[Category: Waterfield, M D.]]
[[Category: Waterfield, M D.]]
[[Category: Signalling protein]]
[[Category: Signalling protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 13:28:08 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:59:28 2008''

Revision as of 02:59, 29 July 2008

File:2pna.png

Template:STRUCTURE 2pna

STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE

Template:ABSTRACT PUBMED 1323062

About this Structure

2PNA is a Single protein structure of sequence from Bos taurus. Full experimental information is available from OCA.

Reference

Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase., Booker GW, Breeze AL, Downing AK, Panayotou G, Gout I, Waterfield MD, Campbell ID, Nature. 1992 Aug 20;358(6388):684-7. PMID:1323062

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