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[[Image:1yui.gif|left|200px]]
{{Seed}}
[[Image:1yui.png|left|200px]]


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{{STRUCTURE_1yui|  PDB=1yui  |  SCENE=  }}  
{{STRUCTURE_1yui|  PDB=1yui  |  SCENE=  }}  


'''SOLUTION NMR STRUCTURE OF THE GAGA FACTOR/DNA COMPLEX, REGULARIZED MEAN STRUCTURE'''
===SOLUTION NMR STRUCTURE OF THE GAGA FACTOR/DNA COMPLEX, REGULARIZED MEAN STRUCTURE===




==Overview==
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The structure of a complex between the DNA binding domain of the GAGA factor (GAGA-DBD) and an oligonucleotide containing its GAGAG consensus binding site has been determined by nuclear magnetic resonance spectroscopy. The GAGA-DBD comprises a single classical Cys2-His2 zinc finger core, and an N-terminal extension containing two highly basic regions, BR1 and BR2. The zinc finger core binds in the major groove and recognizes the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. Unlike the latter, which require tandem zinc finger repeats with a minimum of two units for high affinity binding, the GAGA-DBD makes use of only a single finger complemented by BR1 and BR2. BR2 forms a helix that interacts in the major groove recognizing the last G of the consensus, while BR1 wraps around the DNA in the minor groove and recognizes the A in the fourth position of the consensus. The implications of the structure of the GAGA-DBD-DNA complex for chromatin remodelling are discussed.
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{{ABSTRACT_PUBMED_9033593}}


==About this Structure==
==About this Structure==
1YUI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YUI OCA].  
1YUI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YUI OCA].  


==Reference==
==Reference==
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[[Category: Omichinski, J G.]]
[[Category: Omichinski, J G.]]
[[Category: Chromatin remodeling]]
[[Category: Chromatin remodeling]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:48:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:00:15 2008''

Revision as of 03:00, 29 July 2008

File:1yui.png

Template:STRUCTURE 1yui

SOLUTION NMR STRUCTURE OF THE GAGA FACTOR/DNA COMPLEX, REGULARIZED MEAN STRUCTURE

Template:ABSTRACT PUBMED 9033593

About this Structure

1YUI is a Single protein structure of sequence from Drosophila melanogaster. Full experimental information is available from OCA.

Reference

The solution structure of a specific GAGA factor-DNA complex reveals a modular binding mode., Omichinski JG, Pedone PV, Felsenfeld G, Gronenborn AM, Clore GM, Nat Struct Biol. 1997 Feb;4(2):122-32. PMID:9033593

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