2fwu: Difference between revisions

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[[Image:2fwu.gif|left|200px]]
{{Seed}}
[[Image:2fwu.png|left|200px]]


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{{STRUCTURE_2fwu|  PDB=2fwu  |  SCENE=  }}  
{{STRUCTURE_2fwu|  PDB=2fwu  |  SCENE=  }}  


'''Second Ca2+ binding domain of the Na,Ca-exchanger (NCX1)'''
===Second Ca2+ binding domain of the Na,Ca-exchanger (NCX1)===




==Overview==
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The plasma membrane Na+/Ca2+ exchanger (NCX) is almost certainly the major Ca2+ extrusion mechanism in cardiac myocytes. Binding of Na+ and Ca2+ ions to its large cytosolic loop regulates ion transport of the exchanger. We determined the solution structures of two Ca2+ binding domains (CBD1 and CBD2) that, together with an alpha-catenin-like domain (CLD), form the regulatory exchanger loop. CBD1 and CBD2 are very similar in the Ca2+ bound state and describe the Calx-beta motif. Strikingly, in the absence of Ca2+, the upper half of CBD1 unfolds while CBD2 maintains its structural integrity. Together with a 7-fold higher affinity for Ca2+, this suggests that CBD1 is the primary Ca2+ sensor. Specific point mutations in either domain largely allow the interchange of their functionality and uncover the mechanism underlying Ca2+ sensing in NCX.
The line below this paragraph, {{ABSTRACT_PUBMED_16600866}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16600866 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16600866}}


==About this Structure==
==About this Structure==
2FWU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWU OCA].  
2FWU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FWU OCA].  


==Reference==
==Reference==
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[[Category: Ca2+ binding]]
[[Category: Ca2+ binding]]
[[Category: Greek key]]
[[Category: Greek key]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:24:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:04:29 2008''

Revision as of 03:04, 29 July 2008

File:2fwu.png

Template:STRUCTURE 2fwu

Second Ca2+ binding domain of the Na,Ca-exchanger (NCX1)

Template:ABSTRACT PUBMED 16600866

About this Structure

2FWU is a Single protein structure of sequence from Canis lupus familiaris. Full experimental information is available from OCA.

Reference

Ca2+ regulation in the Na+/Ca2+ exchanger involves two markedly different Ca2+ sensors., Hilge M, Aelen J, Vuister GW, Mol Cell. 2006 Apr 7;22(1):15-25. PMID:16600866

Page seeded by OCA on Tue Jul 29 06:04:29 2008

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