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[[Image:2err.gif|left|200px]]
{{Seed}}
[[Image:2err.png|left|200px]]


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{{STRUCTURE_2err|  PDB=2err  |  SCENE=  }}  
{{STRUCTURE_2err|  PDB=2err  |  SCENE=  }}  


'''NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU'''
===NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU===




==Overview==
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The Fox-1 protein regulates alternative splicing of tissue-specific exons by binding to GCAUG elements. Here, we report the solution structure of the Fox-1 RNA binding domain (RBD) in complex with UGCAUGU. The last three nucleotides, UGU, are recognized in a canonical way by the four-stranded beta-sheet of the RBD. In contrast, the first four nucleotides, UGCA, are bound by two loops of the protein in an unprecedented manner. Nucleotides U1, G2, and C3 are wrapped around a single phenylalanine, while G2 and A4 form a base-pair. This novel RNA binding site is independent from the beta-sheet binding interface. Surface plasmon resonance analyses were used to quantify the energetic contributions of electrostatic and hydrogen bond interactions to complex formation and support our structural findings. These results demonstrate the unusual molecular mechanism of sequence-specific RNA recognition by Fox-1, which is exceptional in its high affinity for a defined but short sequence element.
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{{ABSTRACT_PUBMED_16362037}}


==About this Structure==
==About this Structure==
2ERR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA].  
2ERR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERR OCA].  


==Reference==
==Reference==
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[[Category: Auweter, S D.]]
[[Category: Auweter, S D.]]
[[Category: Protein-rna complex]]
[[Category: Protein-rna complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:02:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:13:27 2008''

Revision as of 03:13, 29 July 2008

File:2err.png

Template:STRUCTURE 2err

NMR Structure of the RNA Binding Domain of Human Fox-1 in Complex with UGCAUGU

Template:ABSTRACT PUBMED 16362037

About this Structure

2ERR is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Molecular basis of RNA recognition by the human alternative splicing factor Fox-1., Auweter SD, Fasan R, Reymond L, Underwood JG, Black DL, Pitsch S, Allain FH, EMBO J. 2006 Jan 11;25(1):163-73. Epub 2005 Dec 15. PMID:16362037

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