2il8: Difference between revisions

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[[Image:2il8.jpg|left|200px]]
{{Seed}}
[[Image:2il8.png|left|200px]]


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{{STRUCTURE_2il8|  PDB=2il8  |  SCENE=  }}  
{{STRUCTURE_2il8|  PDB=2il8  |  SCENE=  }}  


'''THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION'''
===THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION===




==Overview==
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The solution structure of the interleukin 8 (IL-8) dimer has been solved by nuclear magnetic resonance (NMR) spectroscopy and hybrid distance geometry-dynamical simulated annealing calculations. The structure determination is based on a total of 1880 experimental distance restraints (of which 82 are intersubunit) and 362 torsion angle restraints (comprising phi, psi, and chi 1 torsion angles). A total of 30 simulated annealing structures were calculated, and the atomic rms distribution about the mean coordinate positions (excluding residues 1-5 of each subunit) is 0.41 +/- 0.08 A for the backbone atoms and 0.90 +/- 0.08 A for all atoms. The three-dimensional solution structure of the IL-8 dimer reveals a structural motif in which two symmetry-related antiparallel alpha-helices, approximately 24 A long and separated by about 14 A, lie on top of a six-stranded antiparallel beta-sheet platform derived from two three-stranded Greek keys, one from each monomer unit. The general architecture is similar to that of the alpha 1/alpha 2 domains of the human class I histocompatibility antigen HLA-A2. It is suggested that the two alpha-helices form the binding site for the cellular receptor and that the specificity of IL-8, as well as that of a number of related proteins involved in cell-specific chemotaxis, mediation of cell growth, and the inflammatory response, is achieved by the distinct distribution of charged and polar residues at the surface of the helices.
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{{ABSTRACT_PUBMED_2184886}}


==About this Structure==
==About this Structure==
2IL8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA].  
2IL8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IL8 OCA].  


==Reference==
==Reference==
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[[Category: Clore, G M.]]
[[Category: Clore, G M.]]
[[Category: Cytokine]]
[[Category: Cytokine]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 07:37:27 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:18:17 2008''

Revision as of 03:18, 29 July 2008

File:2il8.png

Template:STRUCTURE 2il8

THREE-DIMENSIONAL STRUCTURE OF INTERLEUKIN 8 IN SOLUTION

Template:ABSTRACT PUBMED 2184886

About this Structure

2IL8 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Three-dimensional structure of interleukin 8 in solution., Clore GM, Appella E, Yamada M, Matsushima K, Gronenborn AM, Biochemistry. 1990 Feb 20;29(7):1689-96. PMID:2184886

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