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| [[Image:2fcp.jpg|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_2fcp| PDB=2fcp | SCENE= }} | | {{STRUCTURE_2fcp| PDB=2fcp | SCENE= }} |
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| '''FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) FROM E.COLI'''
| | ===FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) FROM E.COLI=== |
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| ==Overview==
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| FhuA, the receptor for ferrichrome-iron in Escherichia coli, is a member of a family of integral outer membrane proteins, which, together with the energy-transducing protein TonB, mediate the active transport of ferric siderophores across the outer membrane of Gram-negative bacteria. The three-dimensional structure of FhuA is presented here in two conformations: with and without ferrichrome-iron at resolutions of 2.7 and 2.5 angstroms, respectively. FhuA is a beta barrel composed of 22 antiparallel beta strands. In contrast to the typical trimeric arrangement found in porins, FhuA is monomeric. Located within the beta barrel is a structurally distinct domain, the "cork," which mainly consists of a four-stranded beta sheet and four short alpha helices. A single lipopolysaccharide molecule is noncovalently associated with the membrane-embedded region of the protein. Upon binding of ferrichrome-iron, conformational changes are transduced to the periplasmic pocket of FhuA, signaling the ligand-loaded status of the receptor. Sequence homologies and mutagenesis data are used to propose a structural mechanism for TonB-dependent siderophore-mediated transport across the outer membrane.
| | The line below this paragraph, {{ABSTRACT_PUBMED_9856937}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 9856937 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_9856937}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Iron transport protein]] | | [[Category: Iron transport protein]] |
| [[Category: Tonb-dependent receptor]] | | [[Category: Tonb-dependent receptor]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:44:22 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:26:56 2008'' |
