1p98: Difference between revisions

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[[Image:1p98.gif|left|200px]]
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[[Image:1p98.png|left|200px]]


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{{STRUCTURE_1p98|  PDB=1p98  |  SCENE=  }}  
{{STRUCTURE_1p98|  PDB=1p98  |  SCENE=  }}  


'''High-resolution NMR structure of the Ubl-domain of HHR23A'''
===High-resolution NMR structure of the Ubl-domain of HHR23A===




==Overview==
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HHR23A, a protein implicated in nucleotide excision repair, belongs to a class of proteins containing both a ubiquitin-like (Ubl) domain and one or more ubiquitin-associated (UBA) domains, suggesting a role in the ubiquitin-proteasome pathway as well. The Ubl domain binds with high affinity to the second ubiquitin-interacting motif (UIM) of the S5a subunit of the proteasome. Here we present the solution structures of the HHR23A Ubl domain, the second UIM of S5a (UIM-2), and the Ubl:S5a-UIM-2 complex. The HHR23A Ubl domain is structurally similar to ubiquitin. The S5a UIM forms an alpha-helix with an unexpected hairpin loop that contributes to the binding interface with Ubl. The molecular determinants of the Ubl-proteasome interaction are revealed by analysis of the structures, chemical shift mapping, mutant binding studies and sequence conservation.
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{{ABSTRACT_PUBMED_12970176}}


==About this Structure==
==About this Structure==
1P98 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P98 OCA].  
1P98 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P98 OCA].  


==Reference==
==Reference==
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[[Category: Mueller, T D.]]
[[Category: Mueller, T D.]]
[[Category: Ubiquitin-like domain]]
[[Category: Ubiquitin-like domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:50:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:44:21 2008''

Revision as of 03:44, 29 July 2008

File:1p98.png

Template:STRUCTURE 1p98

High-resolution NMR structure of the Ubl-domain of HHR23A

Template:ABSTRACT PUBMED 12970176

About this Structure

1P98 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural determinants for the binding of ubiquitin-like domains to the proteasome., Mueller TD, Feigon J, EMBO J. 2003 Sep 15;22(18):4634-45. PMID:12970176

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