232d: Difference between revisions

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[[Image:232d.gif|left|200px]]
{{Seed}}
[[Image:232d.png|left|200px]]


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{{STRUCTURE_232d|  PDB=232d  |  SCENE=  }}  
{{STRUCTURE_232d|  PDB=232d  |  SCENE=  }}  


'''THE HIGH RESOLUTION CRYSTAL STRUCTURE OF THE DNA DECAMER D(AGGCATGCCT)'''
===THE HIGH RESOLUTION CRYSTAL STRUCTURE OF THE DNA DECAMER D(AGGCATGCCT)===




==Overview==
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The crystal structure of the DNA decamer d(AGGCATGCCT) has been determined to a resolution of 1.3 A and R factor of 13.9%. The structure has a unique conformation with each of the decamer single strands forming base-pairing interactions with two symmetry-related strands. The central eight bases of the decamer form an A-DNA octamer duplex with one symmetry-related strand whilst the terminal 5'-A and T-3' bases are flipped out and away from the octamer helix axis to form base-pairing interactions with a second symmetry-related strand. These A.T base-pairs lie perpendicular to the crystallographic c axis and pack within the unit cell in conjunction with a symmetry-related A.T base-pair displaced by 3.4 A degrees along the c axis. A novel base triplet interaction of the type A*(G.C) is present in the structure with interaction from the major groove side of the terminal 5'-A base to the minor groove of the central A-DNA octamer. This structure reports the first example of cobalt hexammine binding to a right-handed DNA duplex. The crystallographic asymmetric unit contains two cobalt hexammine ligands with one site in the major groove coordinating via hydrogen bonds to the 5'-AGG bases, and the second site located between DNA molecules and interacting with the oxygen atoms of phosphate groups.
The line below this paragraph, {{ABSTRACT_PUBMED_8594201}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8594201 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8594201}}


==About this Structure==
==About this Structure==
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[[Category: Double helix]]
[[Category: Double helix]]
[[Category: Flipped-out base]]
[[Category: Flipped-out base]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:21:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:47:11 2008''

Revision as of 03:47, 29 July 2008

File:232d.png

Template:STRUCTURE 232d

THE HIGH RESOLUTION CRYSTAL STRUCTURE OF THE DNA DECAMER D(AGGCATGCCT)

Template:ABSTRACT PUBMED 8594201

About this Structure

Full crystallographic information is available from OCA.

Reference

The high resolution crystal structure of the DNA decamer d(AGGCATGCCT)., Nunn CM, Neidle S, J Mol Biol. 1996 Feb 23;256(2):340-51. PMID:8594201

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