1jzn: Difference between revisions

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[[Image:1jzn.gif|left|200px]]
{{Seed}}
[[Image:1jzn.png|left|200px]]


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{{STRUCTURE_1jzn|  PDB=1jzn  |  SCENE=  }}  
{{STRUCTURE_1jzn|  PDB=1jzn  |  SCENE=  }}  


'''crystal structure of a galactose-specific C-type lectin'''
===crystal structure of a galactose-specific C-type lectin===




==Overview==
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Rattlesnake venom lectin (RSL) from the western diamondback rattlesnake (Crotalus atrox) is an oligomeric galactose-specific C-type lectin. The X-ray crystal structure of RSL, in complex with lactose and thiodigalactoside, at 2.2 and 2.3 A resolution, respectively, reveals a decameric protein composed of two 5-fold symmetric pentamers arranged in a staggered, back-to-back orientation. Each monomer corresponds to a single canonical C-type lectin carbohydrate recognition domain devoid of accessory domains and is disulfide-bonded to a monomer in the other pentamer. The structure is the first example of that of a carbohydrate complex of a vertebrate galactose-specific C-type lectin. The 10 carbohydrate-binding sites, located on the rim of the decamer, suggest a role for multivalent interactions and a mechanism for RSL's ability to promote receptor cross-linking and cell aggregation.
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{{ABSTRACT_PUBMED_15049685}}


==About this Structure==
==About this Structure==
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[[Category: C-type lectin]]
[[Category: C-type lectin]]
[[Category: Protein-disaccharide complex]]
[[Category: Protein-disaccharide complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 22:07:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:56:22 2008''

Revision as of 03:56, 29 July 2008

File:1jzn.png

Template:STRUCTURE 1jzn

crystal structure of a galactose-specific C-type lectin

Template:ABSTRACT PUBMED 15049685

About this Structure

1JZN is a Single protein structure of sequence from Crotalus atrox. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure., Walker JR, Nagar B, Young NM, Hirama T, Rini JM, Biochemistry. 2004 Apr 6;43(13):3783-92. PMID:15049685

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