2ctn: Difference between revisions

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[[Image:2ctn.jpg|left|200px]]
{{Seed}}
[[Image:2ctn.png|left|200px]]


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{{STRUCTURE_2ctn|  PDB=2ctn  |  SCENE=  }}  
{{STRUCTURE_2ctn|  PDB=2ctn  |  SCENE=  }}  


'''STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES'''
===STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES===




==Overview==
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The regulation of cardiac muscle contraction must differ from that of skeletal muscles to effect different physiological and contractile properties. Cardiac troponin C (TnC), the key regulator of cardiac muscle contraction, possesses different functional and Ca2+-binding properties compared with skeletal TnC and features a Ca2+-binding site I, which is naturally inactive. The structure of cardiac TnC in the Ca2+-saturated state has been determined by nuclear magnetic resonance spectroscopy. The regulatory domain exists in a "closed" conformation even in the Ca2+-bound (the "on") state, in contrast to all predicted models and differing significantly from the calcium-induced structure observed in skeletal TnC. This structure in the Ca2+-bound state, and its subsequent interaction with troponin I (TnI), are crucial in determining the specific regulatory mechanism for cardiac muscle contraction. Further, it will allow for an understanding of the action of calcium-sensitizing drugs, which bind to cardiac TnC and are known to enhance the ability of cardiac TnC to activate cardiac muscle contraction.
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{{ABSTRACT_PUBMED_9218458}}


==About this Structure==
==About this Structure==
2CTN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTN OCA].  
2CTN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CTN OCA].  


==Reference==
==Reference==
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[[Category: Muscle]]
[[Category: Muscle]]
[[Category: Regulatory]]
[[Category: Regulatory]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 23:01:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:34:18 2008''

Revision as of 04:34, 29 July 2008

File:2ctn.png

Template:STRUCTURE 2ctn

STRUCTURE OF CALCIUM-SATURATED CARDIAC TROPONIN C, NMR, 30 STRUCTURES

Template:ABSTRACT PUBMED 9218458

About this Structure

2CTN is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

Reference

Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain., Sia SK, Li MX, Spyracopoulos L, Gagne SM, Liu W, Putkey JA, Sykes BD, J Biol Chem. 1997 Jul 18;272(29):18216-21. PMID:9218458

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