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| [[Image:2nyl.jpg|left|200px]] | | {{Seed}} |
| | [[Image:2nyl.png|left|200px]] |
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| {{STRUCTURE_2nyl| PDB=2nyl | SCENE= }} | | {{STRUCTURE_2nyl| PDB=2nyl | SCENE= }} |
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| '''Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated'''
| | ===Crystal structure of Protein Phosphatase 2A (PP2A) holoenzyme with the catalytic subunit carboxyl terminus truncated=== |
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| ==Overview==
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| Protein Phosphatase 2A (PP2A) plays an essential role in many aspects of cellular physiology. The PP2A holoenzyme consists of a heterodimeric core enzyme, which comprises a scaffolding subunit and a catalytic subunit, and a variable regulatory subunit. Here we report the crystal structure of the heterotrimeric PP2A holoenzyme involving the regulatory subunit B'/B56/PR61. Surprisingly, the B'/PR61 subunit has a HEAT-like (huntingtin-elongation-A subunit-TOR-like) repeat structure, similar to that of the scaffolding subunit. The regulatory B'/B56/PR61 subunit simultaneously interacts with the catalytic subunit as well as the conserved ridge of the scaffolding subunit. The carboxyterminus of the catalytic subunit recognizes a surface groove at the interface between the B'/B56/PR61 subunit and the scaffolding subunit. Compared to the scaffolding subunit in the PP2A core enzyme, formation of the holoenzyme forces the scaffolding subunit to undergo pronounced conformational rearrangements. This structure reveals significant ramifications for understanding the function and regulation of PP2A.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17174897}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17174897 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17174897}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Xu, Y.]] | | [[Category: Xu, Y.]] |
| [[Category: Heat repeat]] | | [[Category: Heat repeat]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:05:04 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:34:32 2008'' |
