1mw5: Difference between revisions

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[[Image:1mw5.jpg|left|200px]]
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{{STRUCTURE_1mw5|  PDB=1mw5  |  SCENE=  }}  
{{STRUCTURE_1mw5|  PDB=1mw5  |  SCENE=  }}  


'''Structure of HI1480 from Haemophilus influenzae'''
===Structure of HI1480 from Haemophilus influenzae===




==Overview==
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The crystal structure of the Haemophilus influenzae protein HI1480 was determined at 2.1-A resolution. The amino acid sequence of HI1480 is unique, having no homology with other known protein sequences. The protein adopts a novel alpha+beta fold, and associates into a dimer of tightly associated dimers. The tight dimers are formed by intermolecular interactions that are mediated by an antiparallel beta-barrel involving both monomers. Helical regions of two dimers mediate the tetramer formation. The helical region contains a four-helix bundle that has been seen only in the anticodon binding domains of class I tRNA synthetases. A cluster of four residues, Tyr18, Arg134, Glu26, and Lys12 is located in a depression formed at the four-helix bundle/ beta-barrel interface. The arrangement is suggestive of an active center, possibly a catalytic site. The HI1480 gene is located within the Mu-like prophage region of H. influenzae, has no homology to bacteriophage genes, and is flanked by transposases. Hence, this is an example of horizontal transfer from an unknown organism. Gel mobility shift assays revealed that HI1480 binds DNA and RNA molecules. Double-stranded DNA is favored over single-stranded DNA, and longer DNA molecules are bound better than shorter ones.
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{{ABSTRACT_PUBMED_15229888}}


==About this Structure==
==About this Structure==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Structure 2 function project]]
[[Category: Structure 2 function project]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:47:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:52:44 2008''

Revision as of 04:52, 29 July 2008

File:1mw5.png

Template:STRUCTURE 1mw5

Structure of HI1480 from Haemophilus influenzae

Template:ABSTRACT PUBMED 15229888

About this Structure

1MW5 is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

Novel structure and nucleotide binding properties of HI1480 from Haemophilus influenzae: a protein with no known sequence homologues., Lim K, Sarikaya E, Galkin A, Krajewski W, Pullalarevu S, Shin JH, Kelman Z, Howard A, Herzberg O, Proteins. 2004 Aug 15;56(3):564-71. PMID:15229888

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