1n1j: Difference between revisions

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[[Image:1n1j.jpg|left|200px]]
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[[Image:1n1j.png|left|200px]]


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{{STRUCTURE_1n1j|  PDB=1n1j  |  SCENE=  }}  
{{STRUCTURE_1n1j|  PDB=1n1j  |  SCENE=  }}  


'''Crystal structure of the NF-YB/NF-YC histone pair'''
===Crystal structure of the NF-YB/NF-YC histone pair===




==Overview==
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The heterotrimeric transcription factor NF-Y recognizes with high specificity and affinity the CCAAT regulatory element that is widely represented in promoters and enhancer regions. The CCAAT box acts in concert with neighboring elements, and its bending by NF-Y is thought to be a major mechanism required for transcription activation. We have solved the structure of the NF-YC/NF-YB subcomplex of NF-Y, which shows that the core domains of both proteins interact through histone fold motifs. This histone-like pair is closely related to the H2A/H2B and NC2alpha/NC2beta families, with features that are both common to this class of proteins and unique to NF-Y. The structure together with the modeling of the nonspecific interaction of NF-YC/NF-YB with DNA and the full NF-Y/CCAAT box complex highlight important structural features that account for different and possibly similar biological functions of the transcriptional regulators NF-Y and NC2. In particular, it emphasizes the role of the newly described alphaC helix of NF-YC, which is both important for NF-Y trimerization and a target for regulatory proteins, such as MYC and p53.
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{{ABSTRACT_PUBMED_12401788}}


==About this Structure==
==About this Structure==
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[[Category: Romier, C.]]
[[Category: Romier, C.]]
[[Category: Histone-like pair]]
[[Category: Histone-like pair]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:58:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:53:24 2008''

Revision as of 04:53, 29 July 2008

File:1n1j.png

Template:STRUCTURE 1n1j

Crystal structure of the NF-YB/NF-YC histone pair

Template:ABSTRACT PUBMED 12401788

About this Structure

1N1J is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The NF-YB/NF-YC structure gives insight into DNA binding and transcription regulation by CCAAT factor NF-Y., Romier C, Cocchiarella F, Mantovani R, Moras D, J Biol Chem. 2003 Jan 10;278(2):1336-45. Epub 2002 Oct 24. PMID:12401788

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