2f33: Difference between revisions

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[[Image:2f33.gif|left|200px]]
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[[Image:2f33.png|left|200px]]


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{{STRUCTURE_2f33|  PDB=2f33  |  SCENE=  }}  
{{STRUCTURE_2f33|  PDB=2f33  |  SCENE=  }}  


'''NMR solution structure of Ca2+-loaded calbindin D28K'''
===NMR solution structure of Ca2+-loaded calbindin D28K===




==Overview==
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Calbindin-D(28K) is a Ca2+-binding protein, performing roles as both a calcium buffer and calcium sensor. The NMR solution structure of Ca2+-loaded calbindin-D(28K) reveals a single, globular fold consisting of six distinct EF-hand subdomains, which coordinate Ca2+ in loops on EF1, EF3, EF4 and EF5. Target peptides from Ran-binding protein M and myo-inositol monophosphatase, along with a new target from procaspase-3, are shown to interact with the protein on a surface comprised of alpha5 (EF3), alpha8 (EF4) and the EF2-EF3 and EF4-EF5 loops. Fluorescence experiments reveal that calbindin-D(28K) adopts discrete hydrophobic states as it binds Ca2+. The structure, binding interface and hydrophobic characteristics of Ca2+-loaded calbindin-D(28K) provide the first detailed insights into how this essential protein may function. This structure is one of the largest high-resolution NMR structures and the largest monomeric EF-hand protein to be solved to date.
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==About this Structure==
==About this Structure==
2F33 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F33 OCA].  
2F33 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F33 OCA].  


==Reference==
==Reference==
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[[Category: Ca2+-binding]]
[[Category: Ca2+-binding]]
[[Category: Ef-hand]]
[[Category: Ef-hand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:01:39 2008''

Revision as of 05:01, 29 July 2008

File:2f33.png

Template:STRUCTURE 2f33

NMR solution structure of Ca2+-loaded calbindin D28K

Template:ABSTRACT PUBMED 16799559

About this Structure

2F33 is a Single protein structure of sequence from Rattus norvegicus. Full experimental information is available from OCA.

Reference

Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D(28K)., Kojetin DJ, Venters RA, Kordys DR, Thompson RJ, Kumar R, Cavanagh J, Nat Struct Mol Biol. 2006 Jul;13(7):641-7. Epub 2006 Jun 25. PMID:16799559

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