1tcs: Difference between revisions

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[[Image:1tcs.jpg|left|200px]]
{{Seed}}
[[Image:1tcs.png|left|200px]]


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{{STRUCTURE_1tcs|  PDB=1tcs  |  SCENE=  }}  
{{STRUCTURE_1tcs|  PDB=1tcs  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF TRICHOSANTHIN-NADPH COMPLEX AT 1.7 ANGSTROMS RESOLUTION REVEALS ACTIVE-SITE ARCHITECTURE'''
===CRYSTAL STRUCTURE OF TRICHOSANTHIN-NADPH COMPLEX AT 1.7 ANGSTROMS RESOLUTION REVEALS ACTIVE-SITE ARCHITECTURE===




==Overview==
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We describe here the crystal structure of the trichosanthin-NADPH complex determined at a resolution of 1.7 A. The adenine base stacks between Tyr 70 and Tyr 111. Arg 163, Glu 160 and Tyr 70 form hydrogen bonds to N(3), O(3') and, through a water molecule, to N(9) of adenosine, respectively. This is the first high resolution structure of a complex between a ribosome-inactivating protein and a substrate analogue, in which the electron density of the N-glycosidic bond is well defined and the preassociated water, thought to be responsible for hydrolyzing the N-C bond, is also explicitly elucidated.
The line below this paragraph, {{ABSTRACT_PUBMED_7634073}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_7634073}}


==About this Structure==
==About this Structure==
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[[Category: Xiong, J P.]]
[[Category: Xiong, J P.]]
[[Category: Toxin]]
[[Category: Toxin]]
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